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Experimental design and z-score results are useful tools for optimizing instrumental neutron activation analysis procedures

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Abstract

In this study 2k experimental designs were used for the optimization of an instrumental neutron activation analysis method for the determination of bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials. Depending on radionuclide half-lives, 23 or 24 experimental designs were used with irradiation time, sample–detector distance, counting time and sample decay time as factors. Gamma ray spectrometer, comparator mass fraction and sample mass were kept constant. Optimized irradiation and measurement conditions were established based on the experimental design results that used z-scores as response on a reference material for the various elements and experimental conditions.

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Acknowledgements

Authors and indebted to the Brazilian Nuclear Energy Commission (CNEN) for financial support and the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES) for the provided grant.

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Authors and Affiliations

  1. Research Reactor Center, Nuclear and Energy Research Institute, Av. Prof. Lineu Prestes, 2242, São Paulo, SP, 05508-000, Brazil

    Uanda P. M. Santos & Edson G. Moreira

  2. School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, São Paulo, SP, 05508-000, Brazil

    Felipe R. Lourenço

Authors
  1. Uanda P. M. Santos
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  2. Felipe R. Lourenço
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  3. Edson G. Moreira
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Correspondence to Edson G. Moreira.

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Santos, U.P.M., Lourenço, F.R. & Moreira, E.G. Experimental design and z-score results are useful tools for optimizing instrumental neutron activation analysis procedures. J Radioanal Nucl Chem 325, 707–718 (2020). https://doi.org/10.1007/s10967-020-07150-4

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  • DOI: https://doi.org/10.1007/s10967-020-07150-4

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