Analysis of radionuclide production in cyclotrons for application in positron emission tomography (PET)

Abstract

The present work focuses on the analysis of nuclear reactions that can occur in a cyclotron for the generation of radionuclides compliant with the restrictions necessary for medical use in a PET. These radionuclides ought to meet some features, such as being positron emitters and having a half-life as short as possible, considering the times of processing and administration of the radiopharmaceutical. The radionuclides studied, 61Cu, 64Cu and 68Ga, meet these conditions. A commercial cyclotron has been modelled with an energy of 18 MeV for protons. Several simulations have been carried out with the model, using different materials as a target. The model validation has been done comparing results with experimental data from the literature.

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Acknowledgements

Authors wish to thank professor Francisco Alves from Institute of Nuclear Sciences Applied to Health (ICNAS) of the University of Coimbra, Portugal, for his suggestions and help providing data to validate the developed model for MCNP.

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Correspondence to José Ródenas.

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Ródenas, J., Jabaloyas, E. Analysis of radionuclide production in cyclotrons for application in positron emission tomography (PET). J Radioanal Nucl Chem 322, 1691–1695 (2019). https://doi.org/10.1007/s10967-019-06903-0

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Keywords

  • Nuclear reactions
  • Cyclotron
  • Monte Carlo
  • Radiopharmaceuticals
  • Positron emission tomography
  • Production of radionuclides