Analysis of radionuclide production in cyclotrons for application in positron emission tomography (PET)

  • José RódenasEmail author
  • Eva Jabaloyas


The present work focuses on the analysis of nuclear reactions that can occur in a cyclotron for the generation of radionuclides compliant with the restrictions necessary for medical use in a PET. These radionuclides ought to meet some features, such as being positron emitters and having a half-life as short as possible, considering the times of processing and administration of the radiopharmaceutical. The radionuclides studied, 61Cu, 64Cu and 68Ga, meet these conditions. A commercial cyclotron has been modelled with an energy of 18 MeV for protons. Several simulations have been carried out with the model, using different materials as a target. The model validation has been done comparing results with experimental data from the literature.


Nuclear reactions Cyclotron Monte Carlo Radiopharmaceuticals Positron emission tomography Production of radionuclides 



Authors wish to thank professor Francisco Alves from Institute of Nuclear Sciences Applied to Health (ICNAS) of the University of Coimbra, Portugal, for his suggestions and help providing data to validate the developed model for MCNP.

Compliance with ethical standards

Conflict of interest

Authors declare that there is no conflict of interest.


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  1. 1.Department of Chemical and Nuclear EngineeringUniversitat Politècnica de ValènciaValenciaSpain

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