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Standardization of the emerging medical positron emitter 89Zr


89Zr is a beta plus and electron capture decaying radionuclide. This paper presents: (1) Absolute standardization by the 4πβ(PC)-γ coincidence method: a new equivalent decay scheme, the mathematical formalism applied to it and the choice of the optimal measurement conditions. (2) Measurements by HPGe gamma-ray spectrometry, to determine the possible impurities, to measure the activity and the relative intensities of the emitted gamma rays. (3) Calibration of the CENTRONIC IG12/20A ionization chamber, by two methods: direct measurement using the absolutely standardized solution and linear least square modelling, as well as their comparison. (4) Comparisons of results of all measurement methods.

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  1. Deri MA, Zeglis BM, Francesconi LC, Lewis JS (2013) PET imaging with 89Zr. From radiochemistry to the clinic. Nucl Med Biol 40:3–14

    Article  CAS  Google Scholar 

  2. Verel I, Visser GMW, Boerman OC, van Eerd JEM, Finn R, Stiter-van Walsum M et al (2003) Long lived positron emitters 89Zr and 124I for scouting of therapeutic radioimmunoconjugates with PET. Cancer Biother Radiopharm 18:655–661

    Article  CAS  Google Scholar 

  3. Qaim S (2017) Nuclear data for production and medical applications of radionuclides. Present status and needs. Nucl Med Biol 44:31–49

    Article  CAS  Google Scholar 

  4. Haddad F, Ferrer L, Guertin A, Carlier T, Michel N, Barbet J, Chatal J-F (2008) ARRONAX, a high-energy and high-intensity cyclotron for nuclear medicine. Eur J Nucl Med Mol Imaging 35:1377–1387

    Article  Google Scholar 

  5. Lake Wooten A, Lewis BC, Szatkowsk D, Sultan DH, Abdin KI, Voller TF, Liu Y, Lapi SE (2016) Calibration setting numbers for dose calibrators for the PET isotopes 52Mn, 64Cu, 76Br, 86Y, 89Zr,124I. Appl Radiat Isot 113:89–95

    Article  Google Scholar 

  6. García-Toraño E, Peyrés V, Roteta M, Mejuto M, Sánchez-Cabezudo A, Romero E (2018) Standardisation and half-life of 89Zr. Appl Radiat Isot 134:421–425

    Article  Google Scholar 

  7. Fenwick A, Keightley J, Collins S, Ferreira K, Robinson A, Evans W, Marshall C (2019) Absolute standardization of 89Zr and determination of nuclear data. In: 22-nd international conference on radionuclide metrology and its applications, ICRM 2019, University of Salamanca, Spain, 27–31 May

  8. Grigorescu EL, Sahagia M, Razdolescu A, Ivan C (1996) Standardization of some electron capture radionuclides. Nucl Instrum Methods Phys Res A 369:414–420

    Article  CAS  Google Scholar 

  9. Nichols AI (2016) Monographie BIPM-5, 89Zr file 8:79–85

  10. Sahagia M, Luca A, Antohe A, Ioan M-R, Cımpeanu C, Barna C, Ivan C (2017) Standardisation of a 68(Ge + Ga) solution within the CCRI(II)-K2.Ge-68 key comparison. J Radioanal Nucl Chem 311:983–990

    Article  CAS  Google Scholar 

  11. Sahagia M, Luca A, Ioan M-R, Antohe A, Ivan C (2018) Standardization of 67Cu and calibration of the ionization chamber. Impurities and decay scheme problems. Appl Radiat Isot 134:297–301

    Article  CAS  Google Scholar 

  12. Sahagia M, Ioan M-R, Antohe A, Luca A, Ivan C (2016) Measurement of I-124. Appl Radiat Isot 109:349–353

    Article  CAS  Google Scholar 

  13. Sahagia M, Waetjen AC, Luca A, Ivan C (2010) IFIN-HH ionization chamber calibration and its validation; electrometric system improvement. Appl Radiat Isot 68:1266–1269

    Article  CAS  Google Scholar 

  14. Pearce AK, Michotte C, Hino Y (2007) Ionization chamber efficiency curves. Metrologia 44:S67–S70

    Article  CAS  Google Scholar 

  15. Amiot MN, Chisté V, Fitzgerald R, Juget F, Michotte C, Pearce A, Ratel G, Zimmerman BE (2015) Uncertainty evaluation in activity measurements using ionization chambers. Metrologia 52:S108–S122

    Article  Google Scholar 

  16. Schräder H (2007) Ionization chambers. Metrologia 44:S53–S66

    Article  Google Scholar 

  17. Sahagia M, Luca A, Antohe A, Ivan C (2012) Standardization of 64Cu and 68Ga by the 4πPC-γ coincidence method and calibration of the ionization chamber. Appl Radiat Isot 70(9):2025–2030

    Article  CAS  Google Scholar 

  18. Sahagia M, Ioan M-R, Luca A, Antohe A, Ivan C, Neacsu B, Ghioca C (2014) Standardization of F-18 and its use for the Romanian PET metrological traceability chain assurance. Appl Radiat Isot 87:14–18

    Article  CAS  Google Scholar 

  19. Singh B (2013) Nuclear data sheets for A = 89. Nucl Data Sheets 114(1):1–208

    Article  CAS  Google Scholar 

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This paper was funded by the joint research project IFA Romania – CEA France No. C5-09/2016

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Correspondence to Maria Sahagia.

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Sahagia, M., Luca, A., Antohe, A. et al. Standardization of the emerging medical positron emitter 89Zr. J Radioanal Nucl Chem 322, 1683–1689 (2019).

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  • Positron emitter 89Zr
  • Absolute standardization
  • 4πβ(PC)-γ coincidence method
  • Gamma-ray spectrometry measurement
  • Calibration of the ionization chamber
  • Comparison of results