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Stability evaluation of Tc-99m radiolabeled GRPr antagonist with amino acid chelators

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Abstract

In order to select a chelator with excellent stability, easier radiolabeling process and low cost, GRPr antagonist RM26 with the amino acid based chelator was radiolabeled with technetium-99m. The stability of the radiolabeled peptides in PBS, serum as well as in the presence of excess cysteine was compared.

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Acknowledgements

This research is financially supported by Science and Technology Development of Foundation of China Academy of Engineering Physics (2014A0301011) and China National Natural Science Foundation (21571164).

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  1. Zhengkun Zhong and Wentao Kan have contributed equally to this work.

Authors and Affiliations

  1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 64 Mianshan Road, Mianyang, 621900, Sichuan, China

    Zhengkun Zhong, Wentao Kan & Wei Liao

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  1. Zhengkun Zhong
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  2. Wentao Kan
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  3. Wei Liao
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Correspondence to Wentao Kan.

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Zhong, Z., Kan, W. & Liao, W. Stability evaluation of Tc-99m radiolabeled GRPr antagonist with amino acid chelators. J Radioanal Nucl Chem 319, 453–458 (2019). https://doi.org/10.1007/s10967-018-6363-6

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  • DOI: https://doi.org/10.1007/s10967-018-6363-6

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