Production routes of 107,109Cd radioisotopes via charged particle induced nuclear reactions


Activation cross sections of application related 107Cd and 109Cd via proton, deuteron, alpha particle induced reactions on palladium, 3He and alpha particle induced nuclear reactions on silver and deuteron induced reactions on cadmium and indium were measured by using the stacked foil irradiation technique and gamma-ray spectrometry. The cross sections were compared with the earlier experimental data and theoretical predictions. Integral yields were deduced on the basis of experimental data. Different production routes for both radioisotopes are compared.

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  1. 1.

    Mukhopadhyay B, Mukhopadhyay K (2011) Applications of the carrier free radioisotopes of second transition series elements in the field of nuclear medicine. Nucl Med Radiat Therapy 2:115

    Google Scholar 

  2. 2.

    Sadeghi M, Mirzaee M, Gholamzadeh Z, Karimian A, Novin FB (2009) Targetry and radiochemistry for no-carrier-added production of Cd-109. Radiochim Acta 97(2):113–116.

    CAS  Article  Google Scholar 

  3. 3.

    Ishikawa S, Suzui N, Ito-Tanabata S, Ishii S, Igura M, Abe T, Kuramata M, Kawachi N, Fujimaki S (2011) Real-time imaging and analysis of differences in cadmium dynamics in rice cultivars (Oryza sativa) using positron-emitting Cd-107 tracer. BMC Plant Biol 11:172.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Fassbender M, Nortier FM, Phillips DR, Hamilton VT, Heaton RC, Jamriska DJ, Kitten JJ, Pitt LR, Salazar LL, Valdez FO, Peterson EJ (2004) Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility. Radiochim Acta 92(4–6):237–243.

    CAS  Article  Google Scholar 

  5. 5.

    Mirzaii M, Sadeghi M, Gholamzadeh Z (2009) Targetry for cyclotron production of no-carrier-added cadmium-109 from Ag-nat(p, n)Cd-109 reaction. Iran J Radiat Res 6(4):201–206

    Google Scholar 

  6. 6.

    Forrest RA, Kalbach WC, Avrigeanu M, Avrigeanu V, Ignatyuk AV, Tárkányi F, Trkov A, Kopecky J, Fischer U (2013) FENDL-3 Library. Final Report of the Coordinated Research Project on Nuclear Data Libraries for Advanced Systems: Fusion Devices INDC(NDS)-0645. IAEA Nuclear Data Section.

  7. 7.

    Gul K, Hermanne A, Mustafa MG, Nortier FM, Oblozinsky P, Qaim SM, Scholten B, Shubin YN, Takács S, Tárkányi F, Zhuang Y (2001) Charged particle cross-section database for medical radioisotope production diagnostic radioisotopes and monitor reactions. Charged particle cross-section database for medical radioisotope production: diagnostic radioisotopes and monitor reactions. Vienna, IAEA. IAEA-TECDOC-1211, IAEA

  8. 8.

    Betak E, Caldeira AD, Capote R, Carlson BV, Choi HD, Guimaraes FB, Ignatyuk AV, Kim SM, Király B, Kovalev SF, Menapace E, Nortier FM, Pompeia P, Qaim SM, Scholten B, Shubin YN, Sublet J-C, Tárkányi F, Nichols AL (2011) Nuclear data for the production of therapeutic radionuclides. Technical Reprots Series, vol 473. IAEA, Vienna

  9. 9.

    IAEA-NDS (2010) Thin layer activation (TLA) technique for wear measurement. IAEA.

  10. 10.

    Hermanne A, Tárkányi F, Takács S, Shubin YN (2005) Experimental determination of cross section of alpha-induced reactions on Pd-nat. Nucl Instrum Methods Phys Res Sect B 229(3–4):321–332.

    CAS  Article  Google Scholar 

  11. 11.

    Uddin MS, Hagiwara M, Baba M, Tárkányi F, Ditrói F (2005) Experimental studies on excitation functions of the proton-induced activation reactions on silver. Appl Radiat Isot 62(4):533–540.

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Uddin MS, Baba M, Hagiwara M, Tárkányi F, Ditrói F, Takács S, Hermanne A (2006) Experimental studies of the deuteron-induced activation cross-sections on Ag-nat. Appl Radiat Isot 64(9):1013–1019

    CAS  Article  Google Scholar 

  13. 13.

    Tárkányi F, Király B, Ditrói F, Takács S, Csikai J, Hermanne A, Uddin MS, Hagiwara M, Baba A, Ido T, Shubin YN, Kovalev SF (2006) Activation cross-sections on cadmium: proton induced nuclear reactions up to 80 MeV. Nucl Instrum Methods Phys Res Sect B 245(2):379–394.

    CAS  Article  Google Scholar 

  14. 14.

    Hermanne A, Tárkányi F, Ditrói F, Takács S, Rebeles RA, Uddin MS, Hagiwara M, Baba M, Shubin Y, Kovalev SF (2006) Experimental study of the excitation functions of proton induced reactions on Sn-nat up to 65 MeV. Nucl Instrum Methods Phys Res Sect B 247(2):180–191.

    CAS  Article  Google Scholar 

  15. 15.

    Tárkányi F, Király B, Ditrói F, Takács S, Csikai J, Hermanne A, Uddin MS, Hagiwara M, Baba M, Ido T, Shubin YN, Kovalev SF (2007) Activation cross sections on cadmium: deuteron induced nuclear reactions up to 40 MeV. Nucl Instrum Methods Phys Res Sect B 259(2):817–828.

    CAS  Article  Google Scholar 

  16. 16.

    Takács S, Hermanne A, Tárkányi F, Ignatyuk A (2010) Cross-sections for alpha particle produced radionuclides on natural silver. Nucl Instrum Methods Phys Res Sect B 268(1):2–12.

    CAS  Article  Google Scholar 

  17. 17.

    Al-Abyad M, Tarkanyi F, Ditroi F, Takacs S (2014) Excitation function of He-3-particle induced nuclear reactions on natural palladium. Appl Radiat Isot 94:191–199.

    CAS  Article  PubMed  Google Scholar 

  18. 18.

    Tárkányi F, Ditrói F, Hermanne A, Takács S, Baba M (2016) Investigation of activation cross sections of proton induced reactions on indium up to 70 MeV for practical applications. Appl Radiat Isot 107:391–400.

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Ditrói F, Tárkányi F, Takács S, Hermanne A, Ignatyuk AV (2017) Activation cross sections of deuteron induced reactions on silver in the 33–50 MeV energy range. Appl Radiat Isot 120:60–65.

    CAS  Article  PubMed  Google Scholar 

  20. 20.

    Canberra (2000)

  21. 21.

    Székely G (1985) Fgm—a flexible gamma-spectrum analysis program for a small computer. Comput Phys Commun 34(3):313–324.

    Article  Google Scholar 

  22. 22.

    Tárkányi F, Szelecsényi F, Takács S (1991) Determination of effective bombarding energies and fluxes using improved stacked-foil technique. Acta Radiol Suppl 376:72

    PubMed  Google Scholar 

  23. 23.

    Tárkányi F, Takács S, Gul K, Hermanne A, Mustafa MG, Nortier M, Oblozinsky P, Qaim SM, Scholten B, Shubin YN, Youxiang Z (2001) Beam monitor reactions (Chapter 4). Charged particle cross-section database for medical radioisotope production: diagnostic radioisotopes and monitor reactions. TECDOC 1211, vol 1211. IAEA

  24. 24.

    NuDat2 database (2.6) (2014) National Nuclear Data Center, Brookhaven National Laboratory.

  25. 25.

    Chu SYF, Ekström LP, Firestone RB (2004) WWW Table of Radioactive Isotopes, version 2.1

  26. 26.

    Q-value calculator (2003) NNDC, Brookhaven National Laboratory.

  27. 27.

    Andersen HH, Ziegler JF (1977) Hydrogen stopping powers and ranges in all elements. The stopping and ranges of ions in matter, vol 3. Pergamon Press, New York

    Google Scholar 

  28. 28.

    International-Bureau-of-Weights-and-Measures (1993) Guide to the expression of uncertainty in measurement, 1st edn. International Organization for Standardization, Geneva

    Google Scholar 

  29. 29.

    Bonardi M (1987) The contribution to nuclear data for biomedical radioisotope production from the Milan cyclotron facility. In: Paper presented at the Consultants Meeting on Data Requirements for Medical Radioisotope Production, Tokyo, Japan

  30. 30.

    Koning AJ, Rochman D (2012) Modern nuclear data evaluation with the TALYS code system. Nucl Data Sheets 113:2841

    CAS  Article  Google Scholar 

  31. 31.

    Koning AJ, Rochman D, Kopecky J, Sublet JC, Bauge E, Hilaire S, Romain P, Morillon B, Duarte H, van der Marck S, Pomp S, Sjostrand H, Forrest R, Henriksson H, Cabellos O, S. G, Leppanen J, Leeb H, Plompen A, Mills R (2015) TENDL-2015: TALYS-based evaluated nuclear data library.

  32. 32.

    Koning AJ, Rochman D, Sublet JC (2017) TENDL-2017 TALYS-based evaluated nuclear data library.

  33. 33.

    Hermanne A, Tárkányi F, Takács S, Ditrói F, Baba M, Ohtshuki T, Spahn I, Ignatyuk AV (2009) Excitation functions for production of medically relevant radioisotopes in deuteron irradiations of Pr and Tm targets. Nucl Instrum Methods Phys Res Sect B 267(5):727–736.

    CAS  Article  Google Scholar 

  34. 34.

    Ignatyuk AV (2010) 2nd RCM on FENDL-3. IAEA.

  35. 35.

    Dityuk AI, Konobeyev AY, Lunev VP, Shubin YN (1998) New version of the advanced computer code ALICE-IPPE. INDC (CCP)-410. IAEA, Vienna

  36. 36.

    Herman M, Capote R, Carlson BV, Oblozinsky P, Sin M, Trkov A, Wienke H, Zerkin V (2007) EMPIRE: nuclear reaction model code system for data evaluation. Nucl Data Sheets 108(12):2655–2715.

    CAS  Article  Google Scholar 

  37. 37.

    Wing J, Huizenga JR (1962) (p, n) cross sections of V51, Cr52, Cu63, Cu65, Ag107, Ag109, Cd111, Cd114, and La139 from 5 to 10.5 MeV. Phys Rev 128(1):280

    CAS  Article  Google Scholar 

  38. 38.

    Khandaker MU, Kim K, Kim KS, Lee M, Kim G, Cho YS, Lee YO (2008) Production cross-sections of residual radionuclides from proton-induced reactions on Ag-nat up to 40 MeV. Nucl Instrum Methods Phys Res Sect B 266(24):5101–5106.

    CAS  Article  Google Scholar 

  39. 39.

    Colle R, Kishore R, Cumming JB (1974) Excitation functions for (p, n) reactions to 25 MeV on 63Cu, 65Cu, and 107Ag. Phys Rev C 9(9):1819–1830

    CAS  Article  Google Scholar 

  40. 40.

    Blaser JP, Boehm F, Marmier P, Peaslee DC (1951) Fonctions d’excitation de la reaction (p, n). I Helv Phys Acta 24:3

    CAS  Google Scholar 

  41. 41.

    Peng XF, Long XG, He FQ, Liu MT (1992) Excitation-functions for Ag-107(D, 2n) Cd-107, Ag-109(D, 2n) Cd-109 and Ag-109(D, P) Ag-110 m reactions. Nucl Instrum Methods Phys Res Sect B 68(1–4):145–148.

    Article  Google Scholar 

  42. 42.

    Long XG, Peng XF, He FQ, Liu MT (1991) Production of Cd-107 and Cd-109 by deuteron bombardment of silver. Appl Radiat Isot 42(12):1234–1236

    CAS  Article  Google Scholar 

  43. 43.

    Misaelides P, Munzel H (1980) Excitation-functions for He-3-induced and alpha-induced reactions with Ag-107 and Ag-109. J Inorg Nucl Chem 42(7):937–948.

    CAS  Article  Google Scholar 

  44. 44.

    Wasilevsky C, Vedoya MD, Nassiff SJ (1985) Excitation-functions for (α, xn) reactions on Ag-107 and Ag-109. J Radioanal Nucl Chem 89(2):531–543.

    CAS  Article  Google Scholar 

  45. 45.

    Hershberger RL, Flynn DS, Gabbard F, Johnson CH (1980) Systematics of proton absorption deduced from (p, p) and (p, n) cross-sections for 2.0- to 6.7-Mev protons on Ag-107, Ag-109 and in-115. Phys Rev C 21(3):896–901.

    CAS  Article  Google Scholar 

  46. 46.

    Johnson CH, Galonsky A, Inskeep CN (1960) Cross sections for (p, n) reactions in intermediate-weight nuclei. Phys Rev A 136:B1719–B1729

    Article  Google Scholar 

  47. 47.

    Bramblett RL, Bonner TW (1960) Neutron evaporation spectra from (p, n) reactions. Nucl Phys 20:395–407

    CAS  Article  Google Scholar 

  48. 48.

    Dmitriev PP, Konstantinov IO, Krasnov NN (1967) Excitation functions of the reactions Ag-109(p, n); Ag-109(d,2n); Ag-107(a,2n + pn) and yield of Cd-109. At Energy 22(4):386

    Article  Google Scholar 

  49. 49.

    Röhm HF, Steyn J, Rautenbach WL, Verwey CJ (1970) Excitation function for the 109Ag(d, 2n)109Cd reaction. J Inorg Nucl Chem 32(5):1413–1417.

    Article  Google Scholar 

  50. 50.

    Weixiang Y, Hanlin L, Wenrong Z, Yiwu Z, Xialin Y (1989) The excitation functions of the Ag-107(d,2n) and (d,p) reactions. Beijing Nat. Tandem Accel. Lab., Prog. Report, vol 103. Beijing, China

  51. 51.

    Nagame Y, Nakamura Y, Takahashi M, Sueki K, Nakahara H (1988) Pre-equilibrium process in He-3-induced reactions on Co-59, Ag-109, Ta-181 and Bi-209. Nucl Phys A 486(1):77–90.

    Article  Google Scholar 

  52. 52.

    Omori T, Yagi M, Yamazaki H, Shiokawa T (1980) Excitation-functions for He-3-induced reactions on silver. Radiochem Radioanal Lett 44(5):307–314

    CAS  Google Scholar 

  53. 53.

    Marten M, Schuring A, Scobel W, Probst HJ (1985) Preequilibrium neutron emission in Ag-109(He-3, Xn) and Cd-111(P, Xn) reactions. Z Phys A Hadron Nucl 322(1):93–103.

    CAS  Article  Google Scholar 

  54. 54.

    Porges KG (1956) Alpha excitation functions of silver and copper. Phys Rev 101:225–230

    CAS  Article  Google Scholar 

  55. 55.

    Patel HB, Gadkari MS, Dave B, Singh NL, Mukherjee S (1996) Analysis of the excitation function of alpha-particle-induced reactions on natural silver. Can J Phys 74(9–10):618–625.

    CAS  Article  Google Scholar 

  56. 56.

    Peng XF, Long XG, He FQ, Liu MT (1996) Excitation functions and yields of the reactions induced by alpha-particle bombardment of natural silver. Appl Radiat Isot 47(3):309–313.

    CAS  Article  Google Scholar 

  57. 57.

    Fukushima S, Hayashi S, Kume S, Okamura H, Otozai K, Sakamoto K, Yoshizawa Y (1963) Excitation functions for the reactions induced by alpha particles on 107Ag. Nucl Phys 41:275–290

    CAS  Article  Google Scholar 

  58. 58.

    Chaubey AK, Bhardwaj MK, Gautam RP, Singh RKY, Ansari MA, Rizvi IA, Singh H (1990) Preequilibrium decay process in the alpha induced reactions of silver isotopes. Appl Radiat Isot 41(4):401–405

    CAS  Article  Google Scholar 

  59. 59.

    Chuvilskaya TV, Seleznev YG, Shirokova AA, Herman M (1999) The analysis of the isomeric yields in the reactions Ag-107, Ag-109(He-6, He-4, n, 2n), K-41(α n) and Pt-193(α n). Izv Akad Nauk Fiz+ 63(5):1032–1036

    CAS  Google Scholar 

  60. 60.

    Haasbroek FJ, Burdzik GF, Cogneau M, Wanet P (1976) Excitation functions and thick-target yields for 67 Ga, 68Ge/68 Ga, 109Cd and 111In induced in natural Zinc and Silver by 100 MeV alpha particles. Council of Scientific and Industrial Research, Pretoria

    Google Scholar 

  61. 61.

    Nortier FM, Mills SJ, Steyn GF (1991) Excitation-functions for the production of Cd-109, In-109 and Sn-109 in proton-bombardment of indium up to 200 MeV. Appl Radiat Isot 42(11):1105–1107

    CAS  Article  Google Scholar 

  62. 62.

    Tárkányi F, Ditrói F, Takács S, Hermanne A, Ignatyuk AV (2015) Extension of the energy range of experimental activation cross-sections data of deuteron induced nuclear reactions on indium up to 50 MeV. Appl Radiat Isot 105:26–31.

    CAS  Article  PubMed  Google Scholar 

  63. 63.

    Skakun EA, Klyucharev AP, Rakivnenko YN, Romanii IA (1975) Excitation-functions of (pn)-Reaction and (p,2n)-reaction on cadmium isotopes. Izv an Sssr Fiz 39(1):24–30

    CAS  Google Scholar 

  64. 64.

    Otozai K, Kume S, Mito A, Okamura H, Tsujino R (1966) Excitation functions for the reactions induced by protons on Cd up to 37 MeV. Nucl Phys 80:335–348

    CAS  Article  Google Scholar 

  65. 65.

    Hermanne A, Rebeles RA, Van den Winkel P, Tarkanyi F, Takacs S (2014) Activation of Cd-112 by deuteron induced reactions up to 50 MeV: An alternative for In-111 production? Nucl Instrum Methods Phys Res Sect B 339:26–33.

    CAS  Article  Google Scholar 

  66. 66.

    Nortier FM, Mills SJ, Steyn GF (1990) Excitation-functions and production-rates of relevance to the production of 111In by proton-bombardment of natCd and natIn up to 100 MeV. Appl Radiat Isot 41(12):1201–1208

    CAS  Article  Google Scholar 

  67. 67.

    Usher OH, Wasilevsky C, Delavegavedoya M, Nassiff SJ (1977) Production cross-sections of in-109g, in-111g, in-113m and Cd-115g formed by deuterons on cadmium. Radiochim Acta 24(2–3):59–63

    Google Scholar 

  68. 68.

    Hermanne A, Adam-Rebeles R, Van den Winkel P, Tarkanyi F, Takacs S (2014) Production of In-111 and (114)mIn by proton induced reactions: an update on excitation functions, chemical separation–purification and recovery of target material. Radiochim Acta 102(12):1111–1126.

    CAS  Article  Google Scholar 

  69. 69.

    Hahn RL (1965) Interactions of cadmium-106 with alpha particles. Phys Rev 137(6B):B1491–B1499

    Article  Google Scholar 

  70. 70.

    Gyürky G, Kiss GG, Elekes Z, Fülöp Z, Somorjai E, Palumbo A, Gorres J, Lee HY, Rapp W, Wiescher M, Ozkan N, Guray RT, Efe G, Rauscher T (2006) alpha-induced cross sections of Cd-106 for the astrophysical p process. Phys Rev C 74(2):025805.

    Article  Google Scholar 

  71. 71.

    Hermanne A, Daraban L, Rebeles RA, Ignatyuk A, Tárkányi F, Takács S (2010) Alpha induced reactions on natCd up to 38.5 MeV: experimental and theoretical studies of the excitation functions. Nucl Instrum Methods Phys Res Sect B 268(9):1376–1391.

    CAS  Article  Google Scholar 

  72. 72.

    Khandaker MU, Kim K, Lee M, Kim G (2014) Investigation of activation cross-sections of alpha-induced nuclear reactions on natural cadmium. Nucl Instrum Methods Phys Res Sect B 333:80–91.

    CAS  Article  Google Scholar 

  73. 73.

    Dmitriev PP, Molin GA (1981) Radioactive nuclide yields for thick target at 22 MeV proton energy. Vop At Nauki i Tekhn SerYadernye Konstanty 44(5):43

    Google Scholar 

  74. 74.

    Landini L, Osso JA (2001) Simultaneous production of Co-57 and Cd-109 in cyclotron. J Radioanal Nucl Chem 250(3):429–431.

    CAS  Article  Google Scholar 

  75. 75.

    Gruverman IJ, Kruger P (1959) Cyclotron-produced carrier-free radioisotopes; thick target yield data and carrier-free separation procedures. Int J Appl Radiat Isot 5(1):21–31

    CAS  Article  Google Scholar 

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The authors acknowledge the support of the respective institutions and the accelerator staffs for providing the beam time and experimental facilities.

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Correspondence to F. Ditrói.

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Tárkányi, F., Ditrói, F., Takács, S. et al. Production routes of 107,109Cd radioisotopes via charged particle induced nuclear reactions. J Radioanal Nucl Chem 318, 1949–1966 (2018).

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  • Medical radioisotopes
  • 107Cd
  • 109Cd
  • Proton, deuteron, 3He and 4He irradiations
  • Nuclear reaction model code
  • Physical yield