Abstract
Methods for chemical separation of terbium from gadolinium and dysprosium have been investigated using proton activated gadolinium, as well as gadolinium–terbium mixture matrix. Terbium radioisotopes can be effectively separated from large amount (> 100 mg) gadolinium on an analytical column. In reactors inactive dysprosium also forms in the activated Gd matrix, considerably decreasing the chemical purity of the labelled radiopharmaceutical. A semi-preparative column method was therefore developed to separate terbium at the same time both from the dysprosium and the gadolinium target material.
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Witzig TE, Flinn IW, Gordon LI, Emmanouilides C, Czuczman MS (2002) J Clin Oncol 20:3262. https://doi.org/10.1200/jco.2002.11.017
Davies AJ, Rohatiner AZS, Howell S, Britton KE, Owens SE (2004) J Clin Oncol 22:1469. https://doi.org/10.1200/jco.2004.06.055
Müller C, Zhernosekov K, Köster U, Johnston K, Dorrer H, Hohn A, van der Walt NT, Türler A, Schibli R (2012) J Nucl Med 53:1951–1959. https://doi.org/10.2967/jnumed.112.107540
Müller C, Vermeulen C, Johnston K, Köster U, Schmid R, Türler A, van der Meulen NP (2016) EJNMMI Res 6:35. https://doi.org/10.1186/s13550-016-0189-4
Dmitriev PP, Molin GA, Dmitrieva ZP (1989) At Energ 66:419
Müller C, Fischer E, Behe M, Köster U, Dorrer H, Reber J, Haller S, Cohrs S, Blanc A, Grünberg J, Bunka M, Zhernosekov K, van der Meulen N, Johnston K, Türler A, Schibli R (2014) Nucl Med Biol 41:e58–e65. https://doi.org/10.1016/j.nucmedbio.2013.11.002
Müller C, Reber J, Haller S, Dorrer H, Bernhardt P, Zhernosekov K, Türler A, Schibli R (2014) Eur J Nucl Med Mol Imaging 41:476–485. https://doi.org/10.1007/s00259-013-2563-z
Kovács Z, Szelcsényi F, Brezovcsik K (2015) J Radioanal Nucl Chem 307:1861–1864. https://doi.org/10.1007/s10967-015-4399-4
Steyn GF, Vermeulen C, Szelecsényi F, Kovács Z, Hohn A, van der Meulen NP, Schibli R, van der Walt TN (2014) Nucl Instrum Methods Phys Res B 319:128–140. https://doi.org/10.1016/j.nimb.2013.11.013
Lehenberger S, Barkhausen C, Cohrs S, Fischer E, Grünberg J, Hohn A, Köster U, Schibli R, Türler A, Zhernosekov K (2011) Nucl Med Biol 38:917–924. https://doi.org/10.1016/j.nucmedbio.2011.02.007
Lehenberger SM (2010) Doktor der Naturwissenschaften genehmigten. Dissertation, Technische Universität München
Rizvi L, Abbas SM, Sarkar S, Goozee G et al (2000) Melanoma Res 10:281. https://doi.org/10.1097/00008390-200006000-00011
Becker CFW, Clayton D, Shapovalov G, Lester HA, Kochendoerfer GG (2004) Bioconjug Chem 15:1118–1124. https://doi.org/10.1021/bc0498828
Tiung DK, Lebedev NA, Main NQ, Khalkin VA (1976) J Radioanal Chem 30:353. https://doi.org/10.1007/bf02516968
van der Meulen N, Vermeulen C, Schibli R, Türler A, Köster U, Müller C (2016) International conference of radioanalytical and nuclear chemistry, 10–15 April, Budapest, Hungary. Book of abstracts, p 96
Firestone RB, Eckström LP (2004) WWW table of radioactive isotopes, version 2.1. http://ie.lbl.gov/toi
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The authors wish to thank the financial support by the Hungarian Research Foundation (Budapest, OTKA K108669).
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Brezovcsik, K., Kovács, Z. & Szelecsényi, F. Separation of radioactive terbium from massive Gd targets for medical use. J Radioanal Nucl Chem 316, 775–780 (2018). https://doi.org/10.1007/s10967-018-5718-3
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DOI: https://doi.org/10.1007/s10967-018-5718-3