Skip to main content
SpringerLink
Log in

Synthesis, bioevaluation and gamma scintigraphy of 99mTc-N-2-(furylmethyl iminodiacetic acid) complex as a new renal radiopharmaceutical

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

A ligand of N-2-(furylmethyl iminodiacetic acid) (FMIDA) has been easily labeled by a tetradentate chelating agent of [99mTc]. Factors like a stannous chloride solution as a reducing agent (100 μg), substrate amount (100 μg), pH (7), in vitro stability (8 h) and temperature (37 °C) have been systematically studied to optimize high radiochemical yield (98.0%). The radiochemical conversion was calculated on thin-layer chromatography, paper electrophoresis, and high performance liquid chromatography. Biodistribution study showed that this complex was removed from the kidneys and bladder path way during 1 h post injection. Therefore, [99mTc]FMIDA may be used as renal function radiotracer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Hosain F, Reba RC, Wagner HN Jr (1969) Int J Appl Radiat Isot 20:517–521

    Article  CAS  Google Scholar 

  2. Bianchi C (1972) Prog Nucl Med 2:21–53

    CAS  Google Scholar 

  3. Skov PE (1970) Acta Med Scand 187:419–428

    Article  CAS  Google Scholar 

  4. Richards P, Atkins HL (1976) J Nucl Med 7:165–170

    Google Scholar 

  5. Mohini B, Drishty S, Sweety S, Haladhar DS, Meera V, Sharmila B (2012) Curr Radiopharm 5:65–70

    Article  Google Scholar 

  6. Malgorzata L, Jeffrey K, Dinesh S, Jonathon AN, Hyunsuk S, Andrew TT (2014) Nucl Med Biol 41:248–253

    Article  Google Scholar 

  7. Malgorzata L, Jeffrey K, Luigi G, Marzilli A, Taylor T (2012) J Nucl Med 53(8):1277–1283

    Article  Google Scholar 

  8. Yoshiharu K, Koji I, Jiro T (1999) Ann Nucl Med 13(2):127–132

    Article  Google Scholar 

  9. Andrew TT, Malgorzata L, Luigi GM (2010) J Nucl Med 51(3):391–396

    Article  Google Scholar 

  10. Jeffrey K, Malgorzata L, Andrew TT, Luigi GM (2012) Eur J Inorg Chem. https://doi.org/10.1002/ejic.201200599

    Google Scholar 

  11. Klingensmith WC, Fritzberg AR, Spitzer VM et al (1984) J Nucl Med 25:42–48

    Google Scholar 

  12. Taylor A, Eshima D, Alazraki N (1987) Eur J Nucl Med 12(10):510–514

    Article  Google Scholar 

  13. González A, Jover L, Mairal LI, Martin-Comin J, Puchal R (1994) Nuklearmedizin 33(6):244–247

    Google Scholar 

  14. Kramer W, Baum RP, Scheuermann E, Hör G, Jonas D (1993) Urol A (in German) 32(2):115–120

    CAS  Google Scholar 

  15. Li Y, Russell CD, Palmer-Lawrence J, Dubovsky EV (1994) J Nucl Med 35(5):846–850

    CAS  Google Scholar 

  16. Al-Nahhas AA, Jafri RA, Britton KE et al (1988) Eur J Nucl Med 14(9–10):453–462

    Article  CAS  Google Scholar 

  17. O’Malley JP, Ziessman HA, Chantarapitak N (1993) Clin Nucl Med 18:22–29

    Article  Google Scholar 

  18. Shattuck LA, Eshima D, Taylor A et al (1994) J Nucl Med 35:349–355

    CAS  Google Scholar 

  19. Brandoni A, Anzai N, Kanai Y, Endou H, Torres AM (2006) Biochim Biophys Acta 1762(7):673–682

    Article  CAS  Google Scholar 

  20. Flannery A, Veber J (1980) A literature review. Med Phys 7:249–250

    Article  CAS  Google Scholar 

  21. Eshima D, Taylor A (1992) Sem Nucl Med 22:61–73

    Article  CAS  Google Scholar 

  22. Esteves FP, Taylor A, Manatunga A, Folks R, Krishnan M, Garcia EV (2006) Am J Roentgenol 187:W610–W617

    Article  Google Scholar 

  23. Alberto R, Abram U (2011) Handbook of nuclear chemistry. Springer, New York, pp 2073–2120

    Book  Google Scholar 

  24. Motaleb MA, El-Said H, Abdallah M, Atef M (2012) Radiochemistry 54(5):501–505

    Article  CAS  Google Scholar 

  25. Chen X, Guo Y, Zhang Q, Hao G, Jia H, Liu B (2008) Organomet. Chem. 693:1822–1828

    Article  CAS  Google Scholar 

  26. Zhuang ZP, Kung MP, Hou C, Plössl K, Kung HF (2005) Nucl Med Bio 32:171–184

    Article  CAS  Google Scholar 

  27. Malgorzata L, Luigi GM, Andrew TT (2009) J Nucl Med 50(3):454–460

    Article  Google Scholar 

  28. Drishty S, Ketaki B, Archana M, Sharmila B, Kanchan K, Meera V (2006) Appl Radiat Isot 64:888–892

    Article  Google Scholar 

  29. Sanad MH, Salama DH, Marzook FA (2017) Radiochim Acta 105(5):389–398

    CAS  Google Scholar 

  30. Sanad MH, Gehan MS, Marzook FA (2017) J Label Compd Radiopharm. https://doi.org/10.1002/jlcr.3541

    Google Scholar 

  31. Rhodes BA (1974) Semin Nucl Med 4:281–293

    Article  CAS  Google Scholar 

  32. Sanad MH  (2013) Radiochemistry 55(5):539–544

    Article  CAS  Google Scholar 

  33. Sanad MH, Challan SB (2017) Radiochemistry 59(3):307–312

    Article  CAS  Google Scholar 

  34. Sanad MH, Talaat HM (2017) Radiochemistry 59(4):396–401

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Labeled Compound Department, Radioisotopes Production and Radioactive Sources Division, Hot Lab. Centre, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. H. Sanad & H. M. Talaat

  2. Applied Org. Chem. Dept., Organic Chemical Industries Division, National Research Center, Cairo, 12622, Egypt

    Alhussein A. Ibrahim

Authors
  1. M. H. Sanad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alhussein A. Ibrahim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. M. Talaat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. H. Sanad.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sanad, M.H., Ibrahim, A.A. & Talaat, H.M. Synthesis, bioevaluation and gamma scintigraphy of 99mTc-N-2-(furylmethyl iminodiacetic acid) complex as a new renal radiopharmaceutical. J Radioanal Nucl Chem 315, 57–63 (2018). https://doi.org/10.1007/s10967-017-5617-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-017-5617-z

Keywords

Search

Navigation