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Production of 89Sr-doped CdSe QDs@PAMAM as the radioanalytical-fluorescent indicator of renal injury and the preliminary application in diabetic nephropathy model

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Abstract

An indicator with double tracers has been developed so as to improve the accuracy and stability of quantitative analysis of renal injury. The indicator based on mono-dispersed 89Sr-doped CdSe QDs@PAMAM with tight core–shell structure and controllable size was synthesized. When intravenously injected in diabetic nephropathy models, the measurements of indicators in urine could effectively reflect the level of renal injury via both radioanalytical and florescent method, and comparable results were obtained with the creatinine in blood. The double trackable indicator of renal injury was capable to indirectly reflect the renal injury with improved accuracy and stability.

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Acknowledgements

This study was funded in part by the Programs of Science and Technology Bureau of Tangshan, Grant Number [10130265a, 05134601A-1].

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Authors and Affiliations

  1. Department of Community Health Care, Tangshan GongRen Hospital, Tangshan, 063000, Hebei, China

    Zhenhong Liu

  2. Department of Nephrology, Tangshan GongRen Hospital, Tangshan, 063000, Hebei, China

    Xiaodong Li

  3. Department of Hemodialysis, Tangshan GongRen Hospital, Tangshan, 063000, Hebei, China

    Xiaoping Liu

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  1. Zhenhong Liu
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  2. Xiaodong Li
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  3. Xiaoping Liu
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Correspondence to Xiaoping Liu.

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Liu, Z., Li, X. & Liu, X. Production of 89Sr-doped CdSe QDs@PAMAM as the radioanalytical-fluorescent indicator of renal injury and the preliminary application in diabetic nephropathy model. J Radioanal Nucl Chem 314, 1701–1706 (2017). https://doi.org/10.1007/s10967-017-5520-7

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  • DOI: https://doi.org/10.1007/s10967-017-5520-7

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