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Radiochemical purity and stability of 99mTc-HMPAO in routine preparations

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Abstract

The aim of this work was to investigate the influence of pH, recovery volume, type of saline solution plastic or glass container, used to prepare the technetium-99m-d,l-hexamethylpropyleneamineoxime ([99mTc]Tc-d,l-HMPAO] radiopharmaceutical starting from generator produced sodium pertechnetate in nuclear medicine routine preparations. We observed that, neither the container type, nor the pH of 0.9% NaCl, used for diluting the [99mTc]pertechnetate, influenced [99mTc]Tc-d,l-HMPAO radiochemical purity (RCP) and stability, that decreased proportionally with the final volume of the preparation. In particular, the RCP of 1 mL kits preparations, at 30 min was found to be less than 80%.

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Acknowledgements

Products are furnished by Nuclear Medicine Unit of University Hospital of Ferrara.

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We declare that we have not received funding, contracts or other forms of personal or institutional funding, with companies whose products are mentioned in the text.

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Authors and Affiliations

  1. Morphology, Surgery and Experimental Medicine Department, University of Ferrara, Via L. Borsari, 46, 44121, Ferrara, FE, Italy

    Licia Uccelli & Alessandra Boschi

  2. Physics and Heart Science Department, University of Ferrara, Via Giuseppe Saragat, 1, 44122, Ferrara, FE, Italy

    Petra Martini & Micol Pasquali

  3. Legnaro National Laboratories, Italian National Institute for Nuclear Physics (LNL-INFN), Viale dell’Università, 2, 35020, Legnaro, PD, Italy

    Petra Martini

Authors
  1. Licia Uccelli
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  2. Petra Martini
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  3. Micol Pasquali
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  4. Alessandra Boschi
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Correspondence to Licia Uccelli.

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Uccelli, L., Martini, P., Pasquali, M. et al. Radiochemical purity and stability of 99mTc-HMPAO in routine preparations. J Radioanal Nucl Chem 314, 1177–1181 (2017). https://doi.org/10.1007/s10967-017-5437-1

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  • DOI: https://doi.org/10.1007/s10967-017-5437-1

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