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Synthesis and biological evaluation of 99mTc-labetalol for β1-adrenoceptor-mediated cardiac imaging

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The objective of this work was to set up a method to formulate a complex for the assessment of myocardial infarction in vivo. Labetalol was successfully labeled with 99mTc using SnCl2·2H2O as reducing agent. Various reaction parameters were investigated to optimize the labeling yield. The labeled complex was stable for up to 24 h. The heart uptake was 35.5 % ID/Organ at 5 min post-injection, while the clearance pathways from the body behave via both the hepatobiliary and renal routes.

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This project was supported by the Deanship of Scientific Research at Prince Sattam bin Abdulaziz University under the research project # 2015/01/3733.

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Correspondence to M. E. Moustapha.

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Moustapha, M.E., Motaleb, M.A. & Sanad, M.H. Synthesis and biological evaluation of 99mTc-labetalol for β1-adrenoceptor-mediated cardiac imaging. J Radioanal Nucl Chem 309, 511–516 (2016).

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