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PET imaging of prostate cancer with 18F-Al-NODA-MATBBN

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Abstract

We explored the application of new bifunctional chelating agent p-SCN-NODA by conjugating to GRPR targeting peptide, MATBBN. p-SCN-NODA can increase the labeling yield to 68.3 ± 1.8 %. 18F-Al-NODA-MATBBN can be produced within 25 min with a radiochemical purity of more than 98 %. At 30 min post-injection, the tumor uptake for 18F-Al-NODA-MATBBN was 3.23 ± 0.23 % ID/g. Biodistribution studies revealed that 18F-Al-NODA-MATBBN was excreted mainly through the kidneys. GRPR-binding specificity was also demonstrated by reduced tumor uptake of 18F-Al-NODA-MATBBN after co-injection with excess unlabeled MATBBN peptide at 1 h post-injection. It suggests that 18F-Al-NODA-MATBBN may be a potential PET tracer candidate for monitoring prostate cancer.

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Acknowledgments

We are grateful to this work is supported by National Natural Science Foundation (21401084, 51473071, 81171399, 81101077, 81472749, 81401450, 81471691), National Significant New Drugs Creation Program (2012ZX09505-001-001), Jiangsu Province Foundation (BE2012622, BL2012031, BM2012066, BE2014609), Outstanding Professional Fund of Health Ministry in Jiangsu Province (RC2011095, Q201204, Q201406, H201529) and Wuxi Hospital Management Center Project (YGZXM14014, YGZXL1316).

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    Authors and Affiliations

    1. Department of Nuclear Medicine, Affiliated Wuxi People’s Hospital, Nanjing Medical University, Wuxi, 214023, Jiangsu, People’s Republic of China

      Fei Chen & Bao Zhu

    2. Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu, People’s Republic of China

      Fei Chen, Donghui Pan, Yuping Xu, Xiufeng Lin, Runlin Yang, Lizhen Wang & Min Yang

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    1. Fei Chen
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    3. Donghui Pan
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    Correspondence to Fei Chen.

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    Fei Chen and Bao Zhu equally contribute to this work.

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    Chen, F., Zhu, B., Pan, D. et al. PET imaging of prostate cancer with 18F-Al-NODA-MATBBN. J Radioanal Nucl Chem 308, 905–911 (2016). https://doi.org/10.1007/s10967-015-4577-4

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