Abstract
Radiochemically pure [188ReX(CO)5] (X = Cl, Br, and I) were prepared for the first time by high-pressure carbonylation of 188ReO4 − with carbon monoxide in an aqueous solution in the presence of halide ions at 210 °C. The complexes were isolated at the n.c.a. level from the reaction mixture by gas-phase transport with carbon monoxide at a high pressure. The procedure allows obtaining the target compounds in any appropriate solvent (aqueous and nonaqueous), which may open new synthetic prospects for the development of novel therapeutic radiopharmaceuticals.
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References
Chart of Nuclides, National Nuclear Data Center. http://www.nndc.bnl.gov
Volkert WA, Hoffman TJ (1999) Therapeutic radiopharmaceuticals. Chem Rev 99:2269–2292
Ponsard B, Hiltunen J, Penttilla P, Vera Ruiz H, Beets AL, Mirzadeh S, Knapp FF Jr (2003) The Tungsten-188/rhenium-188 generator: effective coordination of tungsten-188 production between the HFIR and BR2 reactors. J Radioanal Nucl Chem 257:169–174
Schibli R, Schwarzbach R, Alberto R, Ortner K, Schmalle H, Dumas C, Egli A, Schubiger PA (2002) Steps towards high specific activity labeling of biomolecules for therapeutic application: preparation of precursor [188Re(H2O)3(CO)3]+ and synthesis of tailor-made bifunctional ligand systems. Bioconjugate Chem 13:750–756
Miroslavov AE, Polotskii YS, Gurzhiy VV, Ivanov AYu, Lumpov AA, Tyupina MYu, Sidorenko GV, Tolstoy PM, Maltsev DA, Suglobov DN (2014) Technetium and rhenium pentacarbonyl complexes with C2 and C11 ω-isocyanocarboxylic acid esters. Inorg Chem 53:7861–7869
Alekseev IE, Lazarev VV (2006) Cyclotron production and radiochemical isolation of the therapeutical radionuclide 186Re. Radiochemistry 48:497–500
Miroslavov AE, Lumpov AA, Sidorenko GV, Levitskaya EM, Gorshkov NI, Suglobov DN, Alberto R, Braband H, Gurzhiy VV, Krivovichev SV, Tananaev IG (2008) Complexes of technetium(I) (99Tc, 99mTc) pentacarbonyl core with π-acceptor ligands (tert-butyl isocyanide and triphenylphosphine): crystal structures of [Tc(CO)5(PPh3)]OTf and [Tc(CO)5(CNC(CH3)3)]ClO4. J Organomet Chem 693:4–10
A procedure for preparing technetium pentacarbonyl halides, USSR Inventor’s Certificate no. 1512003, A.S. Kotel’nikova, D.N. Suglobov, A.F. Tsarenko, E.K. Legin, A.E. Miroslavov and G.V. Sidorenko, Byull. Izobret., 1995, 3
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This study was partially supported by the Russian Foundation for Basic Research (Project No. 15-03-04170 A).
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Miroslavov, A.E., Alekseev, I.E., Tyupina, M.Y. et al. Synthesis of [188ReX(CO)5] (X = Cl, Br, and I). J Radioanal Nucl Chem 308, 1039–1042 (2016). https://doi.org/10.1007/s10967-015-4558-7
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DOI: https://doi.org/10.1007/s10967-015-4558-7