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Preliminary evaluation of novel 18F-AlF-NOTA-IF7 as a tumor imaging agent

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Abstract

Annexin 1 (Anxa1) is a highly specific surface marker of tumor vasculature. A carbohydrate ligand-mimicking 7-mer peptide, IFLLWQR (Ile-Phe-Leu–Leu-Trp-Gln-Arg, IF7) can target Anxa1 in tumor vasculature. IF7 was first conjugated with a macrocyclic chelator, 1, 4, 7- triazacyclononane-1, 4, 7- triacetic acid (NOTA), and the resulting bioconjugate NOTA-IF7 was then radiofluorinated via Al18F intermediate to synthesize 18F-AlF-NOTA-IF7. MicroPET studies demonstrated that 18F-AlF-NOTA-IF7 had good uptake in tumor. 18F-AlF-NOTA-IF7 is a promising radiopharmaceutical in tumor imaging. The favorable characterizations of 18F-AlF-NOTA-IF7 such as convenient synthesis, specific Anxa1 targeting and moderate tumor uptake make it possible for imaging of cancers.

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Acknowledgments

This project was supported by the Science Foundation of Health Department of Jiangsu Province (H201226), the Fund of Wuxi Science and Technology Development (CSE31N1409), the Foundation of Wuxi Hospital Management Center (YGZXM14014), National Natural Science Foundation of China (81471736), the Vocational Education Science Foundation of Health Department of Jiangsu Province (JZ201413) and the Health Technology Planning Project of Jiangsu Province (Grant No. Q201204).

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Authors and Affiliations

  1. Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, 214063, Wuxi, Jiangsu, China

    Xiaobo Gu, Donghui Pan, Gangming Cai, Rongjun Zhang & Yaoyuan Zhou

  2. Department of Clinical Laboratory Science, Nanjing Medical University, Affiliated Wuxi Peoples Hospital, 214023, Wuxi, Jiangsu, China

    Mengjun Jiang

  3. Wuxi Higher Health Vocational Technology School, Wuxi, Jiangsu, China

    Yaming Ding

  4. Department of Nuclear Medicine, Nanjing Medical University, Affiliated Wuxi Peoples Hospital, 214023, Wuxi, Jiangsu, China

    Bao Zhu

  5. Department of Pathology, Jiangsu Institute of Nuclear Medicine, 214063, Wuxi, Jiangsu, China

    Xiufeng Lin

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  1. Xiaobo Gu
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  2. Mengjun Jiang
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  3. Donghui Pan
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  4. Gangming Cai
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  7. Yaming Ding
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  8. Bao Zhu
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  9. Xiufeng Lin
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Correspondence to Mengjun Jiang.

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Gu, X., Jiang, M., Pan, D. et al. Preliminary evaluation of novel 18F-AlF-NOTA-IF7 as a tumor imaging agent. J Radioanal Nucl Chem 308, 851–856 (2016). https://doi.org/10.1007/s10967-015-4533-3

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  • DOI: https://doi.org/10.1007/s10967-015-4533-3

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