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Evaluation of 99mTc-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats

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Abstract

Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. The aim of this study was to develop a new radiopharmaceutical for imaging infection. The labeling conditions were optimized, and lyophilized kits were developed for instant preparing. The stability of 99mTc-AMOX in human serum was identified, sterility and pyrogenicity of the radiopharmaceutical were estimated, gamma scintigraphy and in vivo biodistribution with infected rats were investigated. The promising properties of 99mTc-AMOX combined with the development of reliable and instant lyophilized kit afford the opportunity of inflammatory process imaging.

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Acknowledgments

This study was supported by The Scientific and Technological Research Council of Turkey (Tubitak-110 S 229). The authors would like to acknowledge the support of T.R. Prime Ministry State Planning Organization Foundation Grant Project Number: 09DPT001 for TLC Scanner. Also the authors thank to Ege University Nuclear Medicine Department technicians for their technical assistance for the animal experiments.

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Authors and Affiliations

  1. Department of Radiopharmacy, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey

    Derya Ilem-Ozdemir, Oya Caglayan-Orumlu & Makbule Asikoglu

  2. Department of Nuclear Medicine, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey

    Hayal Ozkilic

  3. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey

    Ferda Yilmaz & Mine Hosgor-Limoncu

Authors
  1. Derya Ilem-Ozdemir
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  2. Oya Caglayan-Orumlu
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  3. Makbule Asikoglu
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  4. Hayal Ozkilic
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  5. Ferda Yilmaz
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  6. Mine Hosgor-Limoncu
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Correspondence to Derya Ilem-Ozdemir.

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Ilem-Ozdemir, D., Caglayan-Orumlu, O., Asikoglu, M. et al. Evaluation of 99mTc-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats. J Radioanal Nucl Chem 308, 995–1004 (2016). https://doi.org/10.1007/s10967-015-4516-4

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  • DOI: https://doi.org/10.1007/s10967-015-4516-4

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