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Influence of humidity on radiochemical purity of 99mTc-ECD and 99mTc-Sestamibi

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Abstract

The aim of this study was to evaluate the effect of relative humidity on the stability of the 99mTc ethyl cysteinate dimer radiopharmaceutical. The radiochemical purity and pH of samples stored under controlled temperature and humidity conditions were assessed and compared to a negative control. 99mTc-Sestamibi samples were also analyzed under the same conditions for comparison purposes. The comparative analysis of results by Box and Whisker plots indicated the influence of high relative humidity (90 %) in the 99mTc-ECD stability. No significant changes were observed in the pH of the samples.

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Acknowledgments

The authors would like to thank the Brazilian Nuclear Energy Commission (CNEN); National Council for Scientific and Technological Development (CNPq); Nuclear and Energy Research Institute (IPEN) and Cardiac Emergency of Pernambuco (PROCAPE).

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Authors and Affiliations

  1. Departamento de Energia Nuclear, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, Brazil

    Elaine Vasconcelos dos Santos

  2. Divisão de Produção de Radiofámacos, Centro Regional de Ciências Nucleares do Nordeste – CRCN-NE/CNEN, AV. Prof Luiz Freire, 200, Recife, PE, 50740-540, Brazil

    Mércia Liane de Oliveira & João Eudes do Nascimento

Authors
  1. Elaine Vasconcelos dos Santos
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  2. Mércia Liane de Oliveira
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  3. João Eudes do Nascimento
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Correspondence to Elaine Vasconcelos dos Santos.

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dos Santos, E.V., de Oliveira, M.L. & do Nascimento, J.E. Influence of humidity on radiochemical purity of 99mTc-ECD and 99mTc-Sestamibi. J Radioanal Nucl Chem 306, 751–755 (2015). https://doi.org/10.1007/s10967-015-4424-7

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  • DOI: https://doi.org/10.1007/s10967-015-4424-7

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