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Development of 90Y-chitosan as a new agent for radiosynovectomy

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Abstract

Radiosynovectomy (RSV) has been applied as an effective treatment to the patients with resistant synovitis for more than 50 years. In this research, 90Y-chitosan complex was developed as a new agent for use in RSV. 90Y was obtained from an electrochemical 90Y/90Sr generator. 90Y-chitosan complex was produced with radiochemical purity of higher than 99 % at the optimized condition. Extra-articular leakage of the complex was checked up to 72 h, which demonstrated excellent retention at the injection site. The complex showed significant characteristics which make it as a suitable agent for the management of synovitis.

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Authors and Affiliations

  1. Nuclear Science and Technology Research Institute (NSTRI), 14155-1339, Tehran, Iran

    Samaneh Zolghadri, Hassan Yousefnia & Amir Reza Jalilian

  2. Department of Nuclear Engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran

    Alireza Mirzaei & Mitra Athari-allaf

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  1. Samaneh Zolghadri
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  2. Alireza Mirzaei
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  3. Mitra Athari-allaf
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  4. Hassan Yousefnia
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  5. Amir Reza Jalilian
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Correspondence to Samaneh Zolghadri.

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Zolghadri, S., Mirzaei, A., Athari-allaf, M. et al. Development of 90Y-chitosan as a new agent for radiosynovectomy. J Radioanal Nucl Chem 306, 47–55 (2015). https://doi.org/10.1007/s10967-015-4087-4

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  • DOI: https://doi.org/10.1007/s10967-015-4087-4

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