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18F-radiolabeled analogs of peptide RGD-A7R for simultaneous PET imaging of both αvβ3 and VEGF in tumors

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Abstract

The aim of this paper was to design and synthesis a heterodimeric peptide Arg-Gly-Asp-Tyr-Lys-Ala-Thr-Trp-Leu-Pro-Pro-Arg (RGD-A7R), which is expected to have better performance for dual-receptor targeting. We prepared [18F]AlF-NOTA-RGD-A7R by a direct method with good radiochemical yield and purity in as short as 0.5 h. With reasonably high specificity, this new radio-tracer allowed the visualization of tumors which is VEGF and/or αvβ3 positive. In addition, the tracer also showed favorable pharmacokinetics as an imaging agent.

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Acknowledgments

This work was supported by China National Natural Science Foundation (81000622, 81101066, 51343007, 81101071).

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Authors and Affiliations

  1. Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Road, Shanghai, 200092, China

    Sheng Liang, Yufei Ma, Jun Guo & Hui Wang

  2. Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, 197 Ruijin Road, Shanghai, 200025, China

    Rui Guo

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  1. Sheng Liang
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  2. Yufei Ma
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  3. Jun Guo
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  4. Rui Guo
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  5. Hui Wang
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Correspondence to Hui Wang.

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Liang, S., Ma, Y., Guo, J. et al. 18F-radiolabeled analogs of peptide RGD-A7R for simultaneous PET imaging of both αvβ3 and VEGF in tumors. J Radioanal Nucl Chem 303, 1891–1896 (2015). https://doi.org/10.1007/s10967-014-3689-6

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  • DOI: https://doi.org/10.1007/s10967-014-3689-6

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