Abstract
The researches 99mTc recovery process at presence of divalent Sn(II) were made to determine necessary and sufficient amount of Sn(II), which would provide its full reducibleness in the reaction mixture. That the solution of 99mTc eluate reacts directly with the solution of modified DTPA and SnCl2 the content of radiochemical impurity (RCI) of the unreduced 99mTc(VII) in the labeled nanocolloid is 2.7 %, while the yield of the nanocolloid with the size of 100 nm is approximately 80 %. The results of researches prove the nanocolloid actively gets into the lymphatic system after injection, thus indicating its functional usefulness.
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References
Debroye E, Eliseeva SV, Laurent S, Elst LV, Petoud S, Muller RN, Parac-Vogt TN (2013) Eur J Inorg Chem 14:2629–2639
Powell LW, Thomas MJ (1967) J Clin Pathol 20(6):896–904
Kim DW, Kim WH, Kim MH, Kim CG, Oh CS, Min JJ (2014) Ann Nucl Med 28(5):447–454
Poulin É, Lebel R, Croteau É, Blanchette M, Tremblay L, Lecomte R, Bentourkia M, Lepage M (2014) Magn Reson Med. doi:10.1002/mrm.25151
Kotani K, Kawabe J, Higashiyama S, Yoshida A, Kawamura E, Kawahata H, Yamanaga T, Katayama Y, Shiomi S (2014) Abdom Imaging 39(4):677–684
Silvério S, Torres S, Martins AF, Martins JA, André JP, Helm L, Prata MI, Santos AC, Geraldes CFGC (2009) Dalton Trans 24:4656–4670
Maza S, Valencia R, Geworski L, Zander A, Guski H, Winzer KJ, Munz DL (2003) QJ Nucl Med 30(5):651–688
Sampson CB (1994) Textbook of radiopharmacy theory and practice, vol 3, 2nd edn. Gordon and Breach, London
Vera DR, Wallace AM, Hoh CK, Mattrey RF (2001) J Nucl Med 42(6):951–959
Acknowledgments
This work was done on the unique scientific installation IRT-T reactor and was supported by grant from the Ministry of education and science of Russia (RFMEFI59114X0001).
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Rogov, A.S., Skuridin, V.S., Stasyuk, E.S. et al. Modified DTPA molecule-based nanocolloid radiopharmaceuticals. J Radioanal Nucl Chem 303, 1961–1965 (2015). https://doi.org/10.1007/s10967-014-3628-6
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DOI: https://doi.org/10.1007/s10967-014-3628-6