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Formulation and radiochemical evaluation of a freeze-dried mixed peptide kit for the preparation of 68Ga-labeled peptides for PET imaging of somatostatin receptor positive neuroendocrine cancers

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Abstract

68Ga-labeled DOTA-coupled somatostatin analogue peptides are regularly being used for the PET imaging of patients suspected to be suffering from various types of neuroendocrine cancers over-expressing somatostatin receptors. The article describes the formulation of a freeze-dried mixed peptide kit containing equal amounts of DOTA-TATE and DOTA-NOC and the radiochemical evaluation of the kit for the easy and convenient preparation of 68Ga-labeled mixed radiopeptides. The simultaneous use of two different peptides in the kit is expected to perceive more cancerous lesions and may have a wider applicability in the diagnosis of neuroendocrine cancers.

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Acknowledgments

The authors are grateful to Dr. M.G.R. Rajan, Head, Radiation Medicine Centre, Bhabha Atomic Research Centre (BARC) for kindly providing the 68Ge/68Ga generator, which was used for the present study. The help rendered by the staff members of the animal house facility of BARC during the course of animal studies is thankfully acknowledged.

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Authors and Affiliations

  1. Radiopharmaceuticals Chemistry Section, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    Tapas Das, Mohini Bhadwal & Sharmila Banerjee

  2. Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India

    H. D. Sarma

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  1. Tapas Das
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  2. Mohini Bhadwal
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  3. H. D. Sarma
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  4. Sharmila Banerjee
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Correspondence to Tapas Das.

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Das, T., Bhadwal, M., Sarma, H.D. et al. Formulation and radiochemical evaluation of a freeze-dried mixed peptide kit for the preparation of 68Ga-labeled peptides for PET imaging of somatostatin receptor positive neuroendocrine cancers. J Radioanal Nucl Chem 302, 1259–1264 (2014). https://doi.org/10.1007/s10967-014-3537-8

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  • DOI: https://doi.org/10.1007/s10967-014-3537-8

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