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Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy

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Abstract

Hydroxyapatite was applied as a carrier adsorbing 90Y3+ ions for 90Y-HA colloid production. The radiopharmaceutical colloid was prepared by adding an acidic solution of 90YCl3 to HA suspension in saline solution. Effective parameters on labeling of 90Y-HA were evaluated. Adsorption and cation-exchange properties were studied using inductively coupled plasma elemental analysis and N2 adsorption–desorption isotherm method. Radionuclidic purity was over 99.9 %. Labeling yield and radiochemical purity were >99 %. Radiochemical purity was evaluated also in human albumin for 7 days at 37 °C. Biodistribution studies have shown complete retention of injected radioactivity at the administration site up to 72 h.

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Acknowledgments

The authors are thankful to “The Vise-Presidency of Science and Technology Grant” for their financial support under the project “The Development of new Radiopharmaceuticals in Iran 2010–2012”.

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Correspondence to Hossein A. Khoshhosn.

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Davarpanah, M.R., Khoshhosn, H.A., Harati, M. et al. Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy. J Radioanal Nucl Chem 302, 69–77 (2014). https://doi.org/10.1007/s10967-014-3326-4

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  • DOI: https://doi.org/10.1007/s10967-014-3326-4

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