Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy
Hydroxyapatite was applied as a carrier adsorbing 90Y3+ ions for 90Y-HA colloid production. The radiopharmaceutical colloid was prepared by adding an acidic solution of 90YCl3 to HA suspension in saline solution. Effective parameters on labeling of 90Y-HA were evaluated. Adsorption and cation-exchange properties were studied using inductively coupled plasma elemental analysis and N2 adsorption–desorption isotherm method. Radionuclidic purity was over 99.9 %. Labeling yield and radiochemical purity were >99 %. Radiochemical purity was evaluated also in human albumin for 7 days at 37 °C. Biodistribution studies have shown complete retention of injected radioactivity at the administration site up to 72 h.
KeywordsRadiosynovectomy Rheumatoid arthritis Yttrium-90 Hydroxyapatite Colloidal radiopharmaceuticals Cation exchange
The authors are thankful to “The Vise-Presidency of Science and Technology Grant” for their financial support under the project “The Development of new Radiopharmaceuticals in Iran 2010–2012”.
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