Investigation of the quality of the drug Enalapril commercialized by pharmacies of manipulation in Belo Horizonte, Brazil

Abstract

Samples of Enalapril (C20H28N2O5), a drug largely used to treat hypertension commercialized in Belo Horizonte, Brazil, were analysed applying the k 0-method of neutron activation analysis (k 0-INAA). Medicines prepared according to personalized medical prescription are called manipulated medicines. These analyses aimed at to obtaining complementary data about the quality of the manipulated Enalapril to a survey carried out by the State Health Surveillance Agency of Minas Gerais, Brazil and to determining the presence of impurities in order to perform a preliminary study of the heterogeneity of the samples from each pharmacy. Due to operational reasons, the institutes Centre for Development of Nuclear Technology/Brazilian Commission for Nuclear Energy in Brazil, and Jožef Stefan Institute in Slovenia analysed different set of samples. The results pointed out the presence of: Al, As, Au, Br, Ce, Cl, Co, Cr, Hf, La, Sb, Sc, Sm, Th and Zn. These elements may be originated from the raw material, imported from other countries. Elements such as Cl, Fe, K, Mg and Na could be expected in this kind of samples because they are normally present in the substances used as excipients in the preparation of the medicines. The results for the impurities through the analyses using k 0-INAA method can also be used to verify the heterogeneity of the capsules of the medicines contained in each bottle.

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Acknowledgments

The authors thank FAPEMIG and CAPES for the financial support (Scientific Scholarship to Tatiana Cristina Bomfim Gomes and Fernanda Peixoto Sepe, respectively).

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Correspondence to A. S. Leal.

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Leal, A.S., Menezes, M.A.B.C., Jacimovic, R. et al. Investigation of the quality of the drug Enalapril commercialized by pharmacies of manipulation in Belo Horizonte, Brazil. J Radioanal Nucl Chem 300, 645–651 (2014). https://doi.org/10.1007/s10967-014-3073-6

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Keywords

  • Enalapril
  • Manipulated drugs
  • k 0-INAA