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A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluations

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Abstract

2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-[18F]fluoroethyl)nortropane ([18F]-FECNT) is a potential dopamine transporter PET imaging agent. However, its current radio-synthesis is tedious and time consuming. In this article, we reported a fully automatic method for the synthesis of [18F] FECNT through only one step, using a TRACERlab FXN module, with decay corrected radiochemical yield of 25 ± 5 % (n = 5). The total synthesis time was 50–55 min. The synthesized [18F]FECNT was evaluated in vivo in Parkinson’s disease model rats.

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Acknowledgments

This work was supported by China National Natural Science Foundation (81000622, 30970844 and 81071181).

Conflict of interest

The authors certify that all the affiliations with, or financial involvement in, any organization or entity with a financial interests in or financial conflict with the subject matter of materials discussed in the manuscript are completely disclosed.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Rd., Shanghai, 200092, People’s Republic of China

    Sheng Liang, Yufei Ma, Jun Guo & Hui Wang

  2. The Key Laboratory of Nuclear Medicine, Ministry of Health PRC, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, People’s Republic of China

    Zhengping Chen

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  1. Sheng Liang
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  2. Zhengping Chen
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  3. Yufei Ma
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  4. Jun Guo
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  5. Hui Wang
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Correspondence to Hui Wang.

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Liang, S., Chen, Z., Ma, Y. et al. A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluations. J Radioanal Nucl Chem 298, 1969–1972 (2013). https://doi.org/10.1007/s10967-013-2672-y

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  • DOI: https://doi.org/10.1007/s10967-013-2672-y

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