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Retention profile and selective separation of 90Y from 89Sr using zirconium-vanadate gel packed column

Journal of Radioanalytical and Nuclear Chemistry volume 295, pages 1873–1880 (2013)Cite this article

Abstract

A low cost and selective method has been developed for the separation of trace concentrations of 90Y3+ from its parent 89Sr2+. The proposed procedure is based upon complete retention of 90Y3+ onto zirconium-vanadate (Zr-V) gel ion exchanger packed column from aqueous solutions containing HCl (1.0 × 10−5mol dm−3). Under these conditions, 89Sr2+ species were not retained onto Zr-V sorbent. The retained 90Y3+ species were then recovered with HCl. The performance of Zr-V sorbent packed column was determined via the height equivalent to the theoretical plates (HETP) and the number of plates (N). Validation of the developed method was checked by calculating the radionuclidic purity in terms of purification factor (P f = A/A0) and radiochemical purity of the eluted 90Y from the column. Zr-V sorbent packed column offers unique advantages of retention and quantitative separation of 90Y from retention over conventional solid sorbents in rapid and effective separation of trace concentration of 90Y3+ from 89Sr2+ in their aqueous equilibrium media.

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References

  1. Govindan SV, Goldenberg DM (2010) New antibody conjugates in cancer therapy. Sci World J 10:2070–2089

    Article  CAS  Google Scholar 

  2. Schmidt GP, Paprottka P, Jakobs TF, Hoffmann RT, Baur-Melnyk A, Haug A (2012) FDG-PET-CT and whole-body MRI for triagwe in patients planned for radiombolisation theraby. Eur J Radiol 81:269–276

    Article  Google Scholar 

  3. Matthews KM, Bowyer TW, Saey PRJ, Payne RF (2012) The workshop on signatures of medical and industrial isotope production -WOSMIP; Strassoldo, Italy, 1–3 July 2009. J Environ Radioact 110:1–6

    Article  CAS  Google Scholar 

  4. Theuer CP, Leigh BR, Multani PS, Allen RS, Liang BC (2004) Radioimmunotherapy of non-Hodgkin’s lymphoma: clinical development of the Zevalin regimen. Biotechnol Annu Rev 10:265–295

    Article  CAS  Google Scholar 

  5. Dutta S, Mohapatra PK, Raut DR, Manchanda VK (2011) Preferential extraction of 90Y from 90Sr using N,N,N,N-tetra-2-ethylhexyl diglycolamide (T2EHDGA) as the extractant. J Radioanal Nucl Chem 288:389–394

    Article  CAS  Google Scholar 

  6. Dutta S, Mohapatra PK, Manchanda VK (2011) Separation of 90Y from 90Sr by a solvent extraction method using N,N,N’,N’-tetraoctyl diglycolamide (TODGA) as the extractant. Appl Radiat Isot 69:158–162

    Article  CAS  Google Scholar 

  7. Dutta S, Mohapatra PK, Raut DR, Manchanda VK (1218) Chromatographic separation of carrier free 90Y from 90Sr using a diglycolamide based resin for possible pharmaceutical applications. J Chromatogr A 6483–6488:2011

    Google Scholar 

  8. Bonardi ML, Martano L, Groppi F, Chinol M (2009) Rapid determination of 90Sr impurities in freshly “generator eluted” 90Y for radiopharmaceutical preparation. Appl Radiat Isot 67:1874–1877

    Article  CAS  Google Scholar 

  9. Castillo AX, Perez-Malo M, Isaac-Olive K, Mukhallalati H, Gonzalez EC, Berdeguez MT, Diaz NC (2010) Production of large quantities of 90Y by ion-exchange chromatography using an organic resin and a chelating agent. Nucl Med Biol 37:935–942

    Article  CAS  Google Scholar 

  10. Yusan S, Erenturk S (2012) Adsorption characterization of strontium on PAN/zeolite composite adsorbent. World J Nucl Sci Technol 1:6–12

    Article  Google Scholar 

  11. Chuang JT, Lo JG (1996) Extraction chromatographic separation of carrier-free yttrium-90 from strontium-90/yttrium-90 generator by crown ether-coated silica gels. J Radioanal Nucl Chem 204:83–93

    Article  CAS  Google Scholar 

  12. Hsieha BT, Tinga G, Hsieha HT, Shen LH (1993) Preparation of carrier-free yttrium-90 for medical applications by solvent extraction chromatography. Appl Radiat Isot 44:1473–1480

    Article  Google Scholar 

  13. Bray LA, Wheelwright EJ, Western DW, Carson KJ, Elovich RJ, Shade EH, Alexander DL, Culley GE, Atkin SD (1992) Production of 90Y at Hanford. Radioact Radiochem 3:22–25

    CAS  Google Scholar 

  14. Chinol M, Hnatowich DJ (1987) Generator-produced yttrium-90 for radioimmunotherapy. J Nucl Med Soc Nucl Med 28:1465–1470

    CAS  Google Scholar 

  15. Dhara S, Sarkar S, Basu S, Chattopadhyay P (2009) Separation of the 90Sr-90Y pair with cerium(IV) iodotungstate cation exchanger. Appl Radiat Isot 67:530–534

    Article  CAS  Google Scholar 

  16. Achuthan PV, Dhami PS, Kannan R, Gopalakrishnan V (2000) Separation of carrier-free 90Y from high level waste by extraction chromatographic technique using 2-ethylhexyl-2-ethylhexyl phosphonic acid (KSM-17). Sep Sci Technol 35:261–270

    Article  CAS  Google Scholar 

  17. Malja S, Schomacker K, Malja E (2000) Preparation of 90Y by the 90Sr-90Y generator for medical purpose. J Radioanal Nucl Chem 245:403–406

    Article  Google Scholar 

  18. Chuvilin DY, Khvostionov VE, Markovskij DV, Pavshook VA, Ponomarev-Stepnoy NN, Udovenko AN, Shatrov AV, Vereschagin YI, Rice J, Tome LA (2007) Production of 89Sr in solution reactor. Appl Radiat Isot 65:1087–1094

    Article  CAS  Google Scholar 

  19. Chakravarty R, Pandey U, Manolkar RB, Dash A, Venkatesh M, Pillai MR (2009) Development of an electrochemical 90Sr-90Y generator for separation of 90Y suitable for targeted therapy. Nucl Med Biol 35:245–253

    Article  Google Scholar 

  20. Lewis RF, FU-Mins S, Lane TA, Olewine KR, and Holton PS (2004) In: USPTO (ed) Method and apparatus for separating ions of metallic elements in aqueous solution, G21G1/02 ed. Bristol-Myers Squibb Pharma Company, Princeton

  21. Li W, Wang X, Meng S, Li D, Xiong Y (2007) Extraction and separation of yttrium from the rare earths with sec-octylphenoxy acetic acid in chloride media. Sep Purif Technol 54:164–169

    Article  CAS  Google Scholar 

  22. Chinol M (2006) New designed 90Sr/90Y generator and 90Sr breakthrough determination, development of generator technologies for therapeutic radionuclides. European Institute of Oncology, Milan, pp 65–67

    Google Scholar 

  23. Dutta S, Raut DR, Mohapatra PK (2012) Role of diluent on the separation of 90Y from 90Sr by solvent extraction and supported liquid membrane using T2EHDGA as the extractant. Appl Radiat Isot 70:670–675

    Article  CAS  Google Scholar 

  24. Sylvester P (2005) In: USPTO (ed) Ion exchange materials for the separation of 90Y from 90SR. Lynntech, Inc., College Station

  25. Hui-Bo G, Hong-Sheng B, Xiao-Hai J, Wei Y, Liang-Ge H, Hong-Qiang F (2006) Preparation of a new kind of inorganic adsorbent for 90Y, development of generator technologies for therapeutic radionuclides. European Institute of Oncology, Milan, pp 21–25

    Google Scholar 

  26. Castillo AX (2006) Development of a reproducible methodology for the production of 90Y from 90Sr/90Y chromatographic generator, development of generator technologies for therapeutic radionuclides. European Institute of Oncology, Milan, pp 26–34

    Google Scholar 

  27. Roy K, Mohapatra PK, Rawat N, Pal DK, Basu S, Manchanda VK (2004) Separation of 90Y from 90Sr using zirconium vanadate as the ion exchanger. Appl Radiat Isot 60(5):621–624

    Article  CAS  Google Scholar 

  28. El-Shahawi MS, Kadi MW, El-Khouly SH, Abd El-Mohty A, Saad SM and Eweda NEA (2012) Separation of Y from Sr by zirconium-vanadte gel ion-exchanger sorbent: kinetics and thermodynamic study. J Radioanal Nucl Chem. doi:10.1007/s10967-012-1892-x

  29. Helus F (1983) Radionuclides production. CRC Press, p 39

  30. Roy K, Pal DK, Basus S, Dalia N, Susanta L (2004) Synthesis of a new ion exchanger, zirconium vanadate, and its application to the separation of barium and cesium radionuclides at tracer levels. Appl Radiat Isot 57:471–474

    Article  Google Scholar 

  31. Braun T, Navratil JD, Farag AB (1985) Polyurethane foam sorbents in separation science. CRC Press. Inc, Florida

    Google Scholar 

  32. Malja S, Schomäcker K, Damani G (1997) Preliminary results on labelling antibody Mab B72.3 with 90Y. J Radioanal Nucl Chem 218:255–257

    Article  CAS  Google Scholar 

  33. Cheng Z, Li M, Cao Z, Yang W, and Shengting Z (1995) Studies on the preparation of medical 90Y generator, China Nuclear Information Centre, Atomic Energy Press, document No. SINRE-0151

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Damiatta University, Damiatta, Egypt

    M. S. El-Shahawi

  2. Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Kingdom of Saudi Arabia

    M. S. El-Shahawi & M. W. Kadi

  3. Department of Radioactive Isotopes and Generators, Hot Labs Center, Atomic Energy Authority, Inshas, P.O. Box 13759, Cairo, Egypt

    S. H. El-Khouly & A. Abd El-Mohty

  4. Cyclotron Project, Nuclear Research Center, Atomic Energy Authority, Inshas, P.O. Box 13759, Cairo, Egypt

    S. M. Saad & N. E. A. Eweda

Authors
  1. M. S. El-Shahawi
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  2. M. W. Kadi
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  3. S. H. El-Khouly
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  4. A. Abd El-Mohty
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  5. S. M. Saad
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  6. N. E. A. Eweda
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Correspondence to M. S. El-Shahawi.

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N. E. A. Eweda—deceased

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El-Shahawi, M.S., Kadi, M.W., El-Khouly, S.H. et al. Retention profile and selective separation of 90Y from 89Sr using zirconium-vanadate gel packed column. J Radioanal Nucl Chem 295, 1873–1880 (2013). https://doi.org/10.1007/s10967-012-2262-4

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  • DOI: https://doi.org/10.1007/s10967-012-2262-4

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