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A novel technique for simultaneous diagnosis and radioprotection by radioactive cerium oxide nanoparticles: study of cyclotron production of 137mCe

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An Erratum to this article was published on 04 April 2013

Abstract

Application of nanoparticles in nuclear medicine has aimed to develop diagnosis and therapeutic techniques. Cerium oxide nanoparticles (CNPs) are expected to be useful for protection of healthy tissue from radiation-induced harm and could serve therapeutic function. Among a variety of cerium radioisotopes, 137mCe (T 1/2 = 34.4 h, IT (99.22%), β+ (0.779%)) could be a novel candidate radionuclide in the field of diagnosis owing to its appropriate half-life, 99.91% natural abundance of target and its intense gamma line at 254.29 keV. In this study, 137mCe excitation function via the natLa(p,3n) reaction was calculated by TALYS-1.2 and EMPIRE-3 codes. The excitation function calculations demonstrated that the natLa(p,3n)137mCe reaction leads to the formation of the 136/138Ce isotopic contamination in the 22–35 MeV energy range. Interestingly, the isotopic impurities of 137mCe could serve radio protector function. Overall results indicate that the cyclotron produced 137mCeO2 nanoparticles by irradiation of a target encompassing lanthanum oxide nanoparticles could be a potent alternative for conventional diagnostic radionuclides with simultaneous radioprotection capacity.

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Acknowledgments

The authors wish to express their thanks to Dr. Parvin Sarabadani of the Nanochemistry Laboratory, Agricultural, Medical and Industrial Research School, Iran for very useful discussions. Additionally, the authors would like to thank Mr. Mahdi Bakhtiari of Department of physics, Persian Gulf University, Iran for his supports in the MATLAB®-base calculations of this work. Finally, the authors would like to express their sincere thanks to Dr. Roberto Capote Noy of IAEA Nuclear Data Section, Vienna, Austria for his useful advice on application of the EMPIRE code. This research was supported by WCU (World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R31-2008-10029).

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Authors and Affiliations

  1. Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mohamadreza K. Bakht

  2. Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, P.O. Box 31485/498, Karaj, Tehran, Iran

    Mahdi Sadeghi

  3. Department of Energy Science, Sungkyunkwan University, 300 Cheongcheon-dong, Suwon, Korea

    Claudio Tenreiro

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  1. Mohamadreza K. Bakht
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  2. Mahdi Sadeghi
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  3. Claudio Tenreiro
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Correspondence to Mahdi Sadeghi.

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An erratum to this article can be found online at http://dx.doi.org/10.1007/s10967-013-2485-z.

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Bakht, M.K., Sadeghi, M. & Tenreiro, C. A novel technique for simultaneous diagnosis and radioprotection by radioactive cerium oxide nanoparticles: study of cyclotron production of 137mCe. J Radioanal Nucl Chem 292, 53–59 (2012). https://doi.org/10.1007/s10967-011-1483-2

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