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Determination of iodine concentration in aqueous solutions by proton activation analysis: preliminary results for digested human thyroids

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Abstract

The aim of our studies is to check the possibilities of using proton activation analysis as a competitive method over other analytical techniques applied for iodine determination. It is well known that long-term irradiation of biological samples leads to their decomposition and formation of gaseous radiolysis products, which increase the pressure inside the sample container. In case of using proton beam another problem with liquid samples appears. It is the production of 7Be via spallation reactions 16O(p, spall)7Be. The Compton effect from 7Be γ-line increases the detection limits for isotopes with low-energy γ-lines. AIC-144 cyclotron at The Niewodniczański Institute of Nuclear Physics Polish Academy of Science can accelerate protons up to energy of 60 MeV which is sufficient for (p,5n) reaction needed to obtain 123I (T 1/2 = 13.27 h, Eγ = 159 keV, I = 83%) from stable 127I, thus the Compton effect from 7Be was the main factor perturbing the analysis. Separation and removal of 7Be is required to improve the detection limit. The paper presents a method and an example of its application to the determination of iodine concentration in digested fragments of human thyroids obtained during surgical treatment of patients with different types of thyroid tumor.

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Notes

  1. http://www.irmm.jrc.be/html/reference_materials_catalogue/catalogue/attachements/BCR-279_report.pdf.

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Acknowledgments

The authors wish to thank their colleagues of the AIC—144 cyclotron for their generous support and helpful attitude. This work has been partly supported by the EU Human Capital Operation Program, Polish Project No. POKL.04.0101-00-434/08-00.

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Authors and Affiliations

  1. Department of Nuclear Physical Chemistry, The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342, Kraków, Poland

    Anna K. Wójcik, Paweł Zagrodzki, Jerzy W. Mietelski & Bogdan Wąs

  2. Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, A. Mickiewicza 30 Ave., 30-059, Kraków, Poland

    Anna K. Wójcik

  3. Department of Food Chemistry and Nutrition, Collegium Medicum Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland

    Paweł Zagrodzki

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  1. Anna K. Wójcik
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  2. Paweł Zagrodzki
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  3. Jerzy W. Mietelski
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  4. Bogdan Wąs
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Correspondence to Anna K. Wójcik.

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Wójcik, A.K., Zagrodzki, P., Mietelski, J.W. et al. Determination of iodine concentration in aqueous solutions by proton activation analysis: preliminary results for digested human thyroids. J Radioanal Nucl Chem 291, 415–419 (2012). https://doi.org/10.1007/s10967-011-1276-7

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  • DOI: https://doi.org/10.1007/s10967-011-1276-7

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