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Radiolabeling of codeine with 131I and its biodistribution in rats

  • Radiopharmaceutical Chemistry
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Abstract

Codeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with 131I and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.

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References

  1. Chemistry of the Opium Alkaloids, Committee on Drug Addiction of the Division of Medical Sciences of the National Research, p. 174–334, (1986).

  2. H. Kodaira, S. Spector, Proc. Natl. Acad. Sci., 85 (1988) 1267.

    Article  CAS  Google Scholar 

  3. C. Benedetti, The History of Opium and Its Derivatives in Advances in Pain Research and Therapy, Vol. 14, Ed. Raven Press, New York, Chapter 1 (1990) pp. 1–35.

    Google Scholar 

  4. A. B. Wey, J. Caslavska, W. Thormann, J. Chromatogr. A, 895 (2000) 133.

    Article  CAS  Google Scholar 

  5. S. C. Armstrong, K. L. Cozza, Psychosomatics, 44:6 (2003) 515.

    Article  CAS  Google Scholar 

  6. S. Milo, M. Ansonoff, M. King, G. C. Rossi, A. Zuckerman, J. Pintar, G. W. Pasternak, Cell. Mol. Neurobiol., 26 (2006) 1011.

    Article  CAS  Google Scholar 

  7. S. Spector, I. Munjal, D. E. Schmidt, Brain Res., 915 (2001) 155.

    Article  CAS  Google Scholar 

  8. P. C. Fraker, J. C. Sperk, Biochem. Biophys. Res. Commun., 80 (1978) 849.

    Article  CAS  Google Scholar 

  9. R. Xie, M. Hammarlund-Udenaes, Pharm. Research, 15 (1998) 570.

    Article  CAS  Google Scholar 

  10. R. Mannhold, H. Waterbeemd, J. Comp. Aid. Mol. Des., 15 (2001) 337.

    Article  CAS  Google Scholar 

  11. Z. R. Chen, A. A. Somogyi, G. Reynold, F. Bochner, Br. J. Clin. Pharmac., 31 (1991) 381.

    CAS  Google Scholar 

  12. J. Donnerer, G. Cardinale, J. Coffey, C. A. Lisek, I. Jardin, S. Spector, Am. Soc. Pharm. Exp. Therap., 242 (1987) 583.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Faculty of Arts and Science, Department of Chemistry, Afyon Kocatepe University, 03200, ANS Campus, Afyonkarahisar, Turkey

    H. Enginar

  2. Institute of Nuclear Science, Department of Nuclear Applications, Ege University, Bornova, 35100, Izmir, Turkey

    P. Ünak, F. Y. Lambrecht, E. I. Medine, S. Yolcular, A. Yurt & B. Seyitoğlu

  3. Bolvadin Alkoloid Factory, Bolvadin, Afyonkarahisar, Turkey

    I. Bulduk

Authors
  1. H. Enginar
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  2. P. Ünak
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  3. F. Y. Lambrecht
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  4. F. Z. Biber Müftüler
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  5. E. I. Medine
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  6. S. Yolcular
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  7. A. Yurt
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  8. B. Seyitoğlu
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  9. I. Bulduk
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Correspondence to P. Ünak.

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Enginar, H., Ünak, P., Lambrecht, F.Y. et al. Radiolabeling of codeine with 131I and its biodistribution in rats. J Radioanal Nucl Chem 280, 363–370 (2009). https://doi.org/10.1007/s10967-009-0528-2

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  • DOI: https://doi.org/10.1007/s10967-009-0528-2

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