Skip to main content
Log in

Medical isotope development and supply opportunities in the 21st century

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Research in extending medical isotopes for the diagnosis and treatment of numerous health maladies is hampered by outages and upsets in major supply sources. Investigations in cures for brain cancer (211At), HIV/AIDS virus (213Bi), and even bacterial vectors are either in reduced progress mode or have been cancelled until isotopes become available. Examples of several key radioactive medical isotopes include 99mTc for diagnostics, 131I for non-Hodgkin’s lymphoma and thyroid cancer, 225Ac for acute myelogenous leukemia, and 67Cu for lymphoma cancer. Possibilities for developing commercially viable sources using compact accelerators and next generation research and production reactors are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Yalow RS, Berson SA (1960) J Clin Invest 39:1157 PMID 13846364

    Article  CAS  Google Scholar 

  2. Lequin RM (2005) Clin Chem 51:2415–2418

    Article  CAS  Google Scholar 

  3. Glaxosmithkline, U.S. FDA Lic. 1727, Dec 22 2004

  4. Draximage, INC., NDA 21-305, U. S. CDER, Dec 2, 2002

  5. Satz S, Schenter S (2000) U. S. Patent 6,680,993, Jan 20 2000

  6. Denardo SJ et al (1999) J. Nucl Med 40:302

    CAS  Google Scholar 

  7. Zalutsky MR (2005) Curr J Nucl Med 46(Suppl):151S

    Google Scholar 

  8. Dadachova K et al (2006) PLoS Med 3(11):e427. doi:10.1371/journal.pmed.0030427

    Article  Google Scholar 

  9. World Nuclear Association (2009) Radioisotopes in Medicine, March 2009. Retrieved 27 March 2009 from http://www.world-nuclear.org/info/inf55.html

  10. NAS (2007) Nat. Acad. Press, ISBN: 978-0-309-11067-9, 2007

  11. Coffin D (2008) AECL to discontinue development of the MAPLE reactors, Atomic Energy Canada, Ltd., Mississauga, Canada, May 16, 2008, <http://www.aecl.ca/NewsRoom/News/Press-2008/080516.htm>

  12. Atcher R (2009) 99Mo/99mTc Supply and HEU, [Letter to US Congressmen Edward Markey], March 23, 2009, Retrieved 3 April 2009 from http://interactive.snm.org/docs/SNM%20Letter%20to%20Rep.%20Markey%203.23.09%20FINAL%20with%20report.pdf

  13. Brice J (2008) Diag Imag 30

  14. Kahn J (2009) TCTMD September 09, 2008. Retrieved 27 March 2009 from http://www.tctmd.com/show.aspx?id=69786

  15. OECD Nuclear Energy Agency, OECD Publishing, 2005, ISBN 9264008802, 9789264008809

  16. Katzaroff J (2008) Adv Med Iso Corp, Press Release, March 4, 2008. Retrieved 27 March 2009 from http://www.isotopeworld.com/newsmedia/amicinthenews/297/

  17. Leung K (2005) US Pat. 6,907,097, University of California, June 14, 2005

  18. Tsybin AS (1997) Appl Radiat Isot 48:1577

    Article  CAS  Google Scholar 

  19. Sgouros G, et al (2009) 4th Alpha-Immunotherapy Symposium, 28-29 June 2004, Düsseldorf, Germany. Retrieved 27 Mar 2009 from http://itu.jrc.ec.europa.eu/fileadmin/Documents/Alpha-Immunotherapy/pdf/23_sgour.pdf

  20. Sofou S et al (2004) J Nucl Med 45:253

    CAS  Google Scholar 

  21. Ball RM (1997) United States Patent 5596611

  22. Danon Y, Block RC, TESTA R, Moore H (2008) NS Transactions vol. 98, pp 894–895, 2008 ANS national meeting, Anaheim, CA

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to G. L. Troyer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Troyer, G.L., Schenter, R.E. Medical isotope development and supply opportunities in the 21st century. J Radioanal Nucl Chem 282, 243–246 (2009). https://doi.org/10.1007/s10967-009-0267-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-009-0267-4

Keywords

Navigation