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Determination of the relative oxygenation of samples by ortho-positronium 3-gamma decay for future application in oncology

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Abstract

The exploitation of 3γ imaging may open up a new area of interest in medical positron emission tomography (PET) as a new analytical method to detect hypoxic tumour in oncology. The 3γ yield was measured in normoxic and hypoxic environments where AnaeroGen™ was used to generate the hypoxic environment. The percentage of the coincidence events qualified as 3γ was found to be 26.5% higher in the hypoxic environment.

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Authors and Affiliations

  1. Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK

    M. A. Alkhorayef, E. I. Abuelhia, M. P. W. Chin & N. M. Spyrou

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  1. M. A. Alkhorayef
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  2. E. I. Abuelhia
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  3. M. P. W. Chin
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  4. N. M. Spyrou
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Correspondence to M. A. Alkhorayef.

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Alkhorayef, M.A., Abuelhia, E.I., Chin, M.P.W. et al. Determination of the relative oxygenation of samples by ortho-positronium 3-gamma decay for future application in oncology. J Radioanal Nucl Chem 281, 171–174 (2009). https://doi.org/10.1007/s10967-009-0123-6

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  • DOI: https://doi.org/10.1007/s10967-009-0123-6

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