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S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]: Quality control, characterization and biodistribution studies in rats

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Abstract

fac(S)-[Rh(aet)3] (aet = 2-aminoethanethiolate) is N3S3 metalloligand which can coordinate to transition metal ions to form S-bridge polynuclear complexes. The reaction was carried out between 99mTcO4Na and fac(S)-[Rh(aet)3] in the presence of SnCl2·2H2O. A complex analogous to [Re{Rh(aet3)}2]3+ is formed.6 A simple method for radiolabeling of fac(S)-[Rh(aet)3] with 99mTc has been developed and radiolabeling efficiency was higher than 99%. Effect of SnCl2·2H2O concentration, electrophoresis, HPLC, UV-Visible absorption spectra and biodistribution studies in rats were performed. Higher uptake by kidneys showed rapid distributions of the labeled fac(S)-[Rh(aet)3]. Liver uptake was significant, stomach, lungs and intestine uptake was high at 4 hours post injection time.

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Authors and Affiliations

  1. Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan

    N. Amir, S. Roohi, S. Pervez, A. Mushtaq & M. Jehangir

  2. Department of Chemistry, University of Tsukuba, Tsukuba, 305-8571, Japan

    Y. Miyashita & K. Okamoto

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  1. N. Amir
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  2. S. Roohi
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  3. S. Pervez
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  4. A. Mushtaq
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  5. M. Jehangir
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  6. Y. Miyashita
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  7. K. Okamoto
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Correspondence to N. Amir.

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Amir, N., Roohi, S., Pervez, S. et al. S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]: Quality control, characterization and biodistribution studies in rats. J Radioanal Nucl Chem 279, 25–30 (2009). https://doi.org/10.1007/s10967-007-7244-6

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  • DOI: https://doi.org/10.1007/s10967-007-7244-6

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