Abstract
HPLC technique combined with the simple conventional column solid phase extraction (SPE) chromatography using di-(2-ethylhexyl)orthophosphoric acid (HDEHP) impregnated OASIS-HLB sorbent based SPE resins (OASIS-HDEHP) was developed for the separation of no-carrier added (n.c.a) 177Lu from the bulk quantity of ytterbium target. This combination strategy was based on combining the advantages of the better resolution of HPLC separation of n.c.a 177Lu from the few milligram level Yb target with the high capacity of the OASISHDEHP column for the separation of 177Lu from the bulk Yb target. The production batches of several hundred mCi activity of n.c.a 177Lu radioisotope separated from 50 mg Yb target activated in a nuclear reactor of medium neutron flux (Φ=5·1013 n·cm−2·s−1) were successfully performed using this combined separation technique. With the target irradiation in a reactor of higher thermal neutron flux or with the parallel run of several separation units, several Ci-s of n.c.a 177Lu can be profitably produced on a commercial production basis.
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E. P. Horwitz, D. R. Mc. Alister, A. H. Bond, R. E. Barrans, J. M. Williamson, Appl. Radiation Isotopes, 63 (2005) 23.
M. R. A. Pillai, S. Chakraborty, T. Das, M. Venkatesh, N. Ramamoorthy, Appl. Radiation Isotopes, 59 (2003) 109.
F. F. (Russ) KNAPP Jr., S. Mirzadeh, A. L. Beets, M. Du, J. Radioanal. Nucl. Chem., 263 (2005) 503.
S. Mirzadeh, M. Du, A. L. Beets, F. F. (RUSS) Knapp, United States Patent No. 6,716,353, April 6, 2004.
R. Mikolajczak, J. L. Parus, D. Pawlak, E. Zakrzewska, W. Michalak, I. Sasinowska, J. Radioanal. Nucl. Chem., 257 (2003) 53.
A. R. Ketring, G. J. Ehrhardt, M. F. Embree, K. D. Bailey, T. T. Tyler, J. Gawenis, S. S. Jurisson, H. P. Engelbrecht, C. J. Smith, C. S. Cutler, Alasbimn J., 5 (2003) No. 19, 1.
D. Ma, A. R. Ketring, G. J. Ehrhardt, W. Jia, J. Radioanal. Nucl. Chem., 206 (1996) 119.
K. Hashimoto, H. Matsuoka, S. Uchida, J. Radioanal. Nucl. Chem., 255 (2003) 575.
J. R. Parrington, H. D. Knox, S. L. Breneman, E. M. Baum, F. Feiner, Nuclides and Isotopes, 15 th ed., Lockheed Martin, GE Nuclear Energy, 1996.
Handbook of Nuclear Activation Data, Technical Reports Series No. 273, IAEA, Vienna, 1987.
D. J. Kwekkeboom, W. H. Bakker, P. P. M. Kooij, M. W. Konijnenberg, A. Srinivasan, J. L. Erion, M. A. Schmidt, J. L. Bugaj, M. de Jong, E. P. Krenning, Eur. J. Nucl. Med., 28 (2001) 1319.
Trace Sciences International, Certificate of Analysis #1, Jan, 2003. Trace Sciences International Co. Richmond Hill, ON L4B 3N6 Canada.
N. Morcos, Le Van So, M. Zaw, ANSTO’s Classified Reports ANSTO/C-919-2005 & ANSTO/C-865-2005.
Water Quality Parts®, Chromatography Columns and Supplies Catalogue 2006–2007, Water, USA, 2006, p. 6.
F. Forrer, J. Nucl. Med., 46 (2005) 1310.
S. Lahiri, D. Nayak, M. Nandy, N. R. Das, Appl. Radiation Isotopes, 49 (1998) 911.
N. A. Lebedev, A. F. Novgorodov, R. Misiak, J. Brockmann, F. Rosch, Appl. Radiation Isotopes, 53 (2000) 421.
P. S. Balasubramanian, J. Radioanal. Nucl. Chem., 185 (1994) 305.
L. E. Vera-Avila, E. Camacho, J. Liqu. Chromatogr., 15 (1992) 835.
M. Lochny, R. Odoj, J. Radioanal. Nucl. Chem, 228 (1998) 165.
Le Van So, N. Morcos, J. Radioanal. Nucl. Chem., 277 (2008) 651.
Le Van So, N. Morcos, M. Zaw, P. Pellegrini, I. Greguric, J. Radioanal. Nucl. Chem., 277 (2008) 663.
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Van So, L., Morcos, N., Zaw, M. et al. Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation. J Radioanal Nucl Chem 277, 675–683 (2008). https://doi.org/10.1007/s10967-007-7130-2
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DOI: https://doi.org/10.1007/s10967-007-7130-2