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Two novel procedures of preparation for [Tc(CO)2(NO)]2+labeled by EHIDA and its biodistribution

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Abstract

To develop potential new Tc radiopharmaceuticals, a novel compound [99mTc(CO)2(NO)(EHIDA)]0 (EHIDA: 2,6-diethylphenylcarbamoylmethyliminodiacetic acid) has been prepared by reacting [99mTc(CO)3)(EHIDA)]− with NOBF4 both in water and acetonitrile. The conversion of [99mTc(CO)3)(EHIDA)]− to [99mTc(CO)2(NO)(EHIDA)]0 was supported by TLC, HPLC and eletrophoresis. The radiochemical purity (more than 99%) was proved by TLC and HPLC. The biodistribution in mice demonstrated that [Tc(CO)2(NO)(EHIDA)]0 showed higher uptake in blood, kidney and lung (15 min, blood: 19.24±2.95; kidney: 13.61±3.49; lung: 10.81±1.09.) but a lower uptake in liver (15 min, 5.73±0.74). The slower clearances (120 min, blood: 12.75±1.34; kidney: 13.61±3.49) from blood and kidney were also found. This research describes two methods for the conversion of [99mTc(CO)3]+ into [99mTc(CO)2)(NO)]2+ by using NOBF4 as the source of NO+ both in organic solvent and water. The latter method offers the possibility to introduce the NO-group in high yield in water.

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Authors and Affiliations

  1. Key Laboratory of Radiopharmaceuticals, Beijing Normal University, Ministry of Education, Beijing, P.R. China

    Y. Yang, J. X. Zhang, J. J. Wang & L. Zhu

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  1. Y. Yang
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  2. J. X. Zhang
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  3. J. J. Wang
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  4. L. Zhu
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Yang, Y., Zhang, J.X., Wang, J.J. et al. Two novel procedures of preparation for [Tc(CO)2(NO)]2+labeled by EHIDA and its biodistribution. J Radioanal Nucl Chem 273, 31–36 (2007). https://doi.org/10.1007/s10967-007-0706-z

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  • DOI: https://doi.org/10.1007/s10967-007-0706-z

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