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Biodistribution and imaging of 99mTc-MAVGG-adenine in tumor bearing mice

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Abstract

To increase the tumor uptake of Val-Gly-Gly (VGG), adenine was introduced into the peptide. N-mercaptoacetyl-VGG-adenine (MAVGG-adenine) and MAVGG were labeled with 99mTc using a solution of SnCl2 and tartaric acid as reducing agent. Biodistribution in mice bearing the S180 tumor was measured and γ imaging was performed. Compared with MAVGG, adenine conjugated MAVGG had higher tumor uptake and tumor to normal tissue ratios, which suggested that the tumor uptake property of a peptide may be improved by introducing a nucleotide base. The high contrasted tumor images of 99mTc-MAVGG-adenine also suggested its potential utility as tumor imaging agent.

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  1. Y. L. Zhao

    Present address: Department of Inorganic Chemistry, Beijing Normal University, Beijing, 100875, P.R. China

Authors and Affiliations

  1. Department of Nuclear Medicine, Peking University First Hospital, Beijing, 100034, P.R. China

    C. L. Zhang, Z. L. Fu, F. G. Guo & R. F. Wang

  2. Department of Chemistry, Beijing Normal University, Beijing, 100875, P.R. China

    Y. L. Zhao, S. J. Feng & C. M. Qi

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  1. C. L. Zhang
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Zhang, C.L., Zhao, Y.L., Feng, S.J. et al. Biodistribution and imaging of 99mTc-MAVGG-adenine in tumor bearing mice. J Radioanal Nucl Chem 273, 25–29 (2007). https://doi.org/10.1007/s10967-007-0705-0

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  • DOI: https://doi.org/10.1007/s10967-007-0705-0

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