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Effects of hydroxyl radicals generated from the depleted uranium-hydrogen peroxide systems

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Abstract

A complementary study of hydroxyl radical formation in the depleted uranium (DU)-hydrogen peroxide (H2O2) system and the effect of biosubstances on the system were examined using the spin-trapping method. Hydroxyl radical was formed in the uranyl ion (UO2 2+), 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), and hydrogen peroxide (H2O2) mixture solution. The pseudo first order rate constants of DMPO-OH formation were estimated to be 0.033 s−1 for UO2 2+-H2O2-DMPO solution and 0.153 s−1 for UO2+-H2O2-DMPO solution. The obtained results indicated that the hydroxyl radical formation in the UO2 2+-H2O2 solution could be described as a stepwise reaction process including the reduction of UO2 2+ to UO2 2+ by H2O2 and the Fenton-type reaction of UO2 + with H2O2. Biosubstances, such as proteins, amino acids and saccharides, decreased the DMPO-OH formation, which was caused by the direct hydroxyl radical scavenging and the suppression of hydroxyl radical formation by coupling with uranyl ion.

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Authors and Affiliations

  1. Section of Chemistry, Department of Medical Science, University of Miyazaki, Kiyotake, Miyazaki, 889-1692, Japan

    A. Nakajima

  2. Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, 889-1692, Japan

    Y. Ueda

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  1. A. Nakajima
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  2. Y. Ueda
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Nakajima, A., Ueda, Y. Effects of hydroxyl radicals generated from the depleted uranium-hydrogen peroxide systems. J Radioanal Nucl Chem 272, 251–255 (2007). https://doi.org/10.1007/s10967-007-0510-9

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  • DOI: https://doi.org/10.1007/s10967-007-0510-9

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