Skip to main content
SpringerLink
Log in

Multi-element analysis of bone from the osteogenesis imperfecta model (OIM) mouse using thermal and fast neutron activation analysis

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Osteogenesis imperfecta (OI) is a heritable osteoporotic bone disease, due to defects in either type I procollagen genes (COL1A1 or COL1A2), resulting in abnormal and/or reduced levels of type I procollagen and alterations in bone mineralization. Our long term objectives are to evaluate the impact of proα1(I) and proα2(I) collagen mutations and the role of the genetic background on bone mineralization. Tibias from wildtype, heterozygous (oim/+), and homozygous (oim/oim) animals were subjected to instrumental neutron activation analysis (INAA) to measure F, P, Na, Mg, Cl, Ca, K, and Zn using the University of Missouri Research Reactor (MURR) pneumatic-tube irradiation facility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Osteogenesis Imperfecta Foundation, access date February 27, 2006, http://www.oif.org/site/PageServer?pagename=FastFacts

  2. D. O. Sillence, A. Senn, D. M. Danks, J. Med. Genet., 16 (1979) 101.

    Article  CAS  Google Scholar 

  3. J. Korkko, L. Ala-Kokko, A. De Paepe, L. Nuytinck, J. Earley, D. J. Prockop, Am. J. Hum. Genet., 62 (1998) 98.

    Article  CAS  Google Scholar 

  4. S. D. Chipman, H. O. Sweet, D. J. McBride, M. T. Davisson, S. C. Marks, A. R. Shuldiner, R. J. Wenstrup, D. W. Rowe, J. R. Shapiro, Proc. Natl. Acad. Sci. USA, 90 (1993) 1701.

    Article  CAS  Google Scholar 

  5. C. R. Scriver (Ed.), The Metabolic and Molecular Basis of Inherited Disease, 6th ed., McGraw-Hill, New York, 1989, p. 5241.

    Google Scholar 

  6. D. J. McBride, J. R. Shapiro, Genomics, 20 (1994) 135.

    Article  CAS  Google Scholar 

  7. J. Saban, M. A. Zussman, R. Havey, A. G. Patwardhan, G. B. Schneider, D. King, Bone, 19 (1996) 575.

    Article  CAS  Google Scholar 

  8. M. D. Glascock, W. Z. Tian, W. D. Ehmann, J. Radioanal. Nucl. Chem., 92 (1985) 379.

    Article  CAS  Google Scholar 

  9. T. P. Cheng, J. S. Morris, S. R. Koirtyohann, V. L. Sate, C. K. Baskett, Nucl. Instr. Meth. Phys. Rev., B353 (1994) 457.

    Article  Google Scholar 

  10. C. L. Phillips, D. A. Bradley, C. L. Schlotzhauer, M. Bergfeld, C. Libreros-Minotta, L. R. Gawenis, J. S. Morris, L. L. Clarke, L. S. Hillman, Bone, 27 (2000) 219.

    Article  CAS  Google Scholar 

  11. P.-T. Cheng, S. M. Bader, M. D. Grynpas, Cells Materials, 5 (1995) 271.

    CAS  Google Scholar 

  12. A. Bigi, G. Falini, E. Foresti, M. Gazzano, A. Ripamonti, N. Roveri, J. Inorg. Biochem., 49 (1993) 69.

    Article  CAS  Google Scholar 

  13. A. L. Boskey, C. M. Rimnac, M. Bansal, M. Federman, J. Lian, B. D. Boyan, J. Orthop. Res., 10 (1992) 774.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Missouri Research Reactor Center, Columbia, MO, 65211, USA

    C. E. Huntington & J. S. Morris

  2. Genetics Area Program, University of Missouri-Columbia, Columbia, MO, USA

    S. M. Carleton

  3. Department of Biochemistry, University of Missouri-Columbia, Columbia, MO, USA

    C. L. Phillips

  4. Division of Endocrinology, Diabetes and Nutrition, University of Maryland, Baltimore, MD, USA

    D. J. McBride

Authors
  1. C. E. Huntington
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. M. Carleton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. J. McBride
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. L. Phillips
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. S. Morris
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. E. Huntington.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Huntington, C.E., Carleton, S.M., McBride, D.J. et al. Multi-element analysis of bone from the osteogenesis imperfecta model (OIM) mouse using thermal and fast neutron activation analysis. J Radioanal Nucl Chem 276, 65–69 (2008). https://doi.org/10.1007/s10967-007-0411-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-007-0411-y

Keywords

Search

Navigation