Abstract
The AChE inhibitor (−)-phenserine tartrate is a promising candidate as a treatment for Alzheimer’s disease and tritium labeling of it was required for biological testing. This was accomplished by a halogenation, catalytic tritium dehalogenation strategy resulting in a highly efficient incorporation of tritium. The position of tritium labeling was elucidated by a consideration of both proton and tritium NMR spectra.
This is a preview of subscription content, log in via an institution to check access.
References
S. Asthana, N. H. Greig, L. Hegedus, H. H. Holloway, K. C. Raffaele, M. B. Schapiro, T. T. Soncrant, Clin. Pharmacol. Therap., 58 (1995) 299.
L. A. Sorbera, J. Castaner, Drugs of the Future, 28 (2003) 18.
N. H. Greig, K. Sambamurti, Q.-S. Yu, A. Brossi, G. B. Bruinsma, D. K. Lahiri, Current Alzheimer Res., 2 (2005) 281.
J. A. Egan, R. P. Nugent, C. N. Filer, Appl. Radiation Isotopes, 57 (2002) 837.
X.-F. Pei, N. H. Greig, J. L. Flippen-Anderson, S. Bi, A. Brossi, Helv. Chim. Acta, 77 (1994) 1412.
A. Brossi, X.-F. Pei, N. H. Greig, Aust. J. Chem., 49 (1996) 171.
J. Allen, G. Parent, A. Tizot, J. Label. Comp. Radiopharm., 23 (1986) 807.
A. O. K. Nieminen, H. Haataja, M. Rautio, E. Rahkamaa, J. Heterocyclic Chem., 20 (1983) 515.
S. Murao, H. Hayashi, Agric. Biol. Chem., 50 (1986) 523.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lacy, J.M., Pounds, S. & Filer, C.N. Synthesis of the AChE inhibitor [phenyl-7-3H] (−)-phenserine tartrate at high specific activity. J Radioanal Nucl Chem 275, 221–223 (2008). https://doi.org/10.1007/s10967-006-6973-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10967-006-6973-2