Summary
Crotoxin (Crtx) is the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom. Research on antitumoral drugs has demonstrated the potential use of Crtx as tumour reducing agent. Tissue distribution studies are very important for clinical use and 99mTc-labeling is a very convenient method for studies related to biodistribution. The aim of the present study was to label Crtx with 99mTc keeping its biological activity for use in biodistribution and binding studies. High labeling yield was obtained using stannous chloride and sodium borohydride. Results demonstrated that biological activity of 99mTc-Crtx was preserved and confirmed kidneys as the target organ. Biological activities of unlabeled and 99mTc-labeled Crtx were evaluated after labeling. 99mTc-Crtx can be a useful tool for imaging and binding studies.
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Novais, C., Pujatti, P., Castro, M. et al. 99mTc radiolabeling of crotoxin as a tool for biodistribution studies. J Radioanal Nucl Chem 269, 591–595 (2006). https://doi.org/10.1007/s10967-006-0270-y
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DOI: https://doi.org/10.1007/s10967-006-0270-y