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Characterization and application of the fac-[188Re(CO)3(H2O)3]+ core

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Fac-[188Re(CO)3(H2O)3]+ was synthesized with an overall radiochemical yield of 80±5%, and more than 95% radiochemical purity after a QMA Sep-Pak column separation. Fac-[Re(CO)3(H2O)3]+ was also synthesized as a reference sample. The structure of the precursor, fac-[188Re(CO)3(H2O)3]+, was confirmed by high performance of liquid chromatography (HPLC). MN-His (magnetic nanoparticles coated with silica and modified with an amino silane coupling agent, N-[3-(trimethyoxysilyl)propyl]-ethylenediamine (SG-Si900) and immobilized with histidine) was labeled with fac-[188Re(CO)3(H2O)3]+ and an initial animal test of MN-His was conducted for a magnetic targeting study.

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Authors and Affiliations

  1. Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China

    Jiaoyun Xia

  2. Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China

    Yongxian Wang

  3. Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China

    Junfeng Yu

  4. Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China

    Jinquan Cao

  5. Shanghai Institute of Nuclear Research, Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China

    Chunfu Zhang

  6. Radiopharmaceutical Research Center, Shanghai Institute of Applied Physics, Graduate School of the Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P.R. China

    Duanzhi Yin

Authors
  1. Jiaoyun Xia
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  2. Yongxian Wang
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  3. Junfeng Yu
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  4. Jinquan Cao
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  5. Chunfu Zhang
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  6. Duanzhi Yin
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Xia, J., Wang, Y., Yu, J. et al. Characterization and application of the fac-[188Re(CO)3(H2O)3]+ core. J Radioanal Nucl Chem 266, 313–316 (2005). https://doi.org/10.1007/s10967-005-0909-0

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  • DOI: https://doi.org/10.1007/s10967-005-0909-0

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