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Development of chitosan beads for controlled release of dexamethasone prepared by co-axial needle method

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Abstract

Preparation of dexamethasone (Dex)-loaded chitosan beads were developed applying a surface-response methodology. The operational conditions were optimized with the aim of maximizing the loading capacity of Dex. The loading of the drug within the chitosan beads was carried out by ionotropic gelation technique with tetra sodium phosphate (TSP) as cross-linking agent with co-axial method that compared with simple mixing method. The co-axial method included loading of drug during dripping process using two separate syringes, simultaneously. The highest drug loading capacity for beads prepared by mixing and co-axial method was obtained 53% and 98% respectively. The beads were evaluated for surface and bulk morphology using SEM. The beads produced from mixing showed a good spherical shape with a smooth surface but co-axial method led to form a wrinkle surface. Bulk structure of Dex-loaded beads in both preparation methods had several crack regions. The optimized drug-loaded chitosan beads prepared by co-axial method revealed during drug release in the range of 40 to 80 days and percent cumulative drug released was between 25% and 50%. Drug release kinetic study was investigated via fitting with two diffusion-based semi-empirical models. Also, the rate constants and diffusion exponent for the drug release were calculated. The drug release was predicted to be Fickian and/ or quasi-Fickian diffusion.

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Authors and Affiliations

  1. Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran

    Melica Zakeri, Hamid Mobedi, Ahmad Jamshidi & Arezou Mashak

  2. Department of Biomaterials, Faculty of Science, Iran Polymer and Petrochemical Institute, P.O.Box:14965/115, Tehran, Iran

    Jalal Barzin

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  1. Melica Zakeri
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  2. Hamid Mobedi
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Correspondence to Hamid Mobedi.

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Zakeri, M., Mobedi, H., Barzin, J. et al. Development of chitosan beads for controlled release of dexamethasone prepared by co-axial needle method. J Polym Res 27, 254 (2020). https://doi.org/10.1007/s10965-020-02232-z

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