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PMAA nanogel controllably releases anti-IL-1β IgY for treating allergic rhinitis

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Abstract

Intranasal glucocorticoid spray is the preferred method to treat allergic rhinitis. However, due to the instantaneous high drug concentration, there are still some side effects, such as nasal dryness, nasal bleeding and even systemic effect of glucocorticoid. Herein, a novel biocompatible poly(methacrylic acid) (PMAA) nanogel was synthesized and used to load anti-IL-1β IgY (IgY) for treating allergic rhinitis induced by ovalbumin. The results indicated that PMAA nanogel had sustained-released effect of IgY in vitro. Symptoms of allergic rhinitis were remarkably relieved after the topical intranasal drip treatment using IgY/PMAA nanogel. The number of eosinophilic granulocyte in nasal lavage fluid and in nasal mucosa tissue, the expression of IL-1β analysis revealed that IgY/PMAA nanogel had a good controlled-released therapeutic effect, and IgY/PMAA nanogel exhibited lower in vivo toxicity in the experimental range, which suggested a promising potential for allergic rhinitis treatment with less side effect.

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Abbreviations

PMAA:

Poly (methacrylic acid)

IL-1:

Interleukin-1

IL-6:

Interleukin-6

IL-8:

Interleukin-8

Th2:

T-helper 2 cells

GM-CSF:

Granulocyte-macrophage colony stimulating factor

anti-IL-1β:

Anti-Interleukin-1 beta

IgY:

Immunoglobulin of yolk

IgE:

Serum immunoglobulin

MUC5AC:

Mucins 5 ac

In vitro:

Within the glass

In vivo:

Within the living

AR:

Allergic rhinitis

OVA-induced:

Ovalbumin-induced

FT-IR:

Fourier transform infrared

SEM:

Scanning electron microscopy

DLS:

Dynamic laser light-scattering

MAA:

Methacrylic acid

CH3CN:

Acetonitrile

EGDMA:

Ethylene glycol dimethacrylate

AIBN:

2,2′-azobisisobutyronitrile

LC :

Load content

LE :

Load efficiency

WA :

Water absorption

PBS:

Phosphate Buffered Saline

NLF:

Nasal lavage fluid

HE:

Hematoxylin-eosin

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Acknowledgements

The authors acknowledged financial support from the National Natural Science Foundation of China (81573000, 81260406, 21476052), the Foundation of Science and Technology Projects of Guangdong Province (2016A010103047, 2016A070711023), the Science and Technology Innovation Platform Project of Foshan City (2016AG100541, 2017AG100092), the Foshan Technology Research Center (2016GA10161), the talent introduction fund of Guangdong Provincial People’s Hospital (Y012018142), and the Project supported by GDHVPS (2017).

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Author notes

  1. Ting Wu and Tao Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan, 528041, People’s Republic of China

    Ting Wu, Jinglin Zhang, Fenfen Wei & Xiang Cai

  2. Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China

    Tao Liu & Shaohua Chen

  3. College of Agriculture, Anshun University, Anshun, 561000, China

    Xiling Zhu

  4. Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China

    Yonghe Li

  5. Department of Pharmacology, Jiangxi Testing Center of Medical Instruments, Nanchang, 330029, China

    Xidong Wu

  6. Faculty of Basic Medicine, 2015 Grade, Zhongshan School of Medicine, Sun Yat-sen University, Guizhou, 510080, China

    Mengying Xia

  7. Institute of Clinical Medical Sciences, Jiangxi Province People’s Hospital, Nanchang, 330006, China

    Zhixian Lv, Wenyun Zhou & Guozhu Hu

  8. The No.1 Surgery Department of No.5 People’s Hospital of Foshan, Foshan, 528211, People’s Republic of China

    Shaobin Yu

  9. Guangdong Gaoming Industrial Innovation Research Institute, Foshan, 528500, People’s Republic of China

    Xiang Cai

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  1. Ting Wu
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Correspondence to Guozhu Hu, Shaohua Chen or Xiang Cai.

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Wu, T., Liu, T., Zhu, X. et al. PMAA nanogel controllably releases anti-IL-1β IgY for treating allergic rhinitis. J Polym Res 26, 185 (2019). https://doi.org/10.1007/s10965-019-1846-x

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