Dual stimuli-responsive supramolecular polymeric nanoparticles based on poly(α-cyclodextrin) and acetal-modified β-cyclodextrin-azobenzene
To aim at pH environment in tumor tissue and light-controlled drug release, UV and pH dual-responsive supramolecular polymeric nanoparticles mediated by host-guest interactions of poly(α-cyclodextrin) and acetal-modified β-cyclodextrin-azobenzene were developed in this work. The host molecule was poly(α-cyclodextrin) and the guest molecule was composed of acetal-modified β-cyclodextrin with one azobenzene linked. The inclusion of α-cyclodextrin and azobenzene leaded to amphiphilic supramolecular polymer, which further self-assembled to form supramolecular polymeric nanoparticles in aqueous medium. UV and pH responsiveness of supramolecular polymeric nanoparticles attributed to azobenzene and acetal, respectively. Supramolecular polymeric nanoparticles based on poly(α-cyclodextrin) and acetal-modified β-cyclodextrin-azobenzene with the average diameter of sub-100 nm were controllable to release the drugs regulated by pH and UV.
KeywordsCyclodextrin pH-responsive Supramolecular chemistry UV-responsive Polymeric nanoparticles
This work was financially supported by the National Natural Science Foundation of China (Nos. 51703209 and 21603196), the Natural Science Foundation of Hubei Province (No. 2017CFB217), and the Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) (Nos. CUG170601 and CUGL170406).
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