Advertisement

Journal of Polymer Research

, 24:203 | Cite as

Preparation of poly (vinyl alcohol)/gelatin composites via in-situ thermal/mechanochemical degradation of collagen fibers during melt extrusion: effect of extrusion temperature

  • Hongchao Lu
  • Yuansen Liu
  • Yujun Yang
  • Li LiEmail author
ORIGINAL PAPER

Abstract

By in-situ degradation of collagen fibers into gelatin under the thermal/mechanochemical effects of the extruder, PVA/gelatin composites were successfully prepared using PVA and collagen fibers derived from cattle hide limed split wastes as raw materials. The effect of extrusion temperature on the degradation of collagen fibers and the thermal processability and mechanical properties of the composites were studied. The results showed that the controllable degradation of collagen fibers in extruder could be realized by adjusting the extrusion temperature. Particularly, high extrusion temperature promoted the generation of low-molecular-weight gelatin and the esterification between the hydroxyl of PVA and the carboxyl of gelatin, as well as the hydrogen bonding between O-H, C = O, N-H in gelatin and water or O-H in PVA, thus endowing gelatin with the good compatibility with PVA, and significantly increasing the content of non-freezable bound water in system. Ascribing to the plasticization of the gelatin with lower molecular weight and more non-freezable bound water, PVA/gelatin composites exhibited the improved thermal processability and the decreased mechanical properties with the increase of extrusion temperature. Even so, the tensile strength and Young’s modulus of the composite obtained at 175 °C still above 40 MPa and 1.0 GPa respectively, satisfying some practical applications.

Keywords

Poly (vinyl alcohol) Collagen fibers In-situ degradation Extrusion temperature Thermal processability 

Notes

Acknowledgements

The authors greatly acknowledge the financial support of the International Science and Technology Cooperation Program of China (2013DFG52300) and the Program of Innovative Research Team for Young Scientists of Sichuan Province (2016TD0010).

References

  1. 1.
    Baker MI, Walsh SP, Schwartz Z, Boyan BD (2012) A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. J Biomed Mater Res B Appl Biomater 100B:1451–1457.  https://doi.org/10.1002/jbm.b.32694 CrossRefGoogle Scholar
  2. 2.
    Merkle VM, Tran PL, Hutchinson M, Ammann KR, DeCook K, Wu X, Slepian MJ (2015) Core–shell PVA/gelatin electrospun nanofibers promote human umbilical vein endothelial cell and smooth muscle cell proliferation and migration. Acta Biomater 27:77–87.  https://doi.org/10.1016/j.actbio.2015.08.044 CrossRefGoogle Scholar
  3. 3.
    Liao H, Shi K, Peng J, Qu Y, Liao J, Qian Z (2015) Preparation and properties of Nano-hydroxyapatite/gelatin/poly(vinyl alcohol) composite membrane. J Nanosci Nanotechnol 15(6):4188–4192.  https://doi.org/10.1166/jnn.2015.9722 CrossRefGoogle Scholar
  4. 4.
    Shankhwar N, Kumar M, Mandal BB, Srinivasan A (2016) Novel polyvinyl alcohol-bioglass 45S5 based composite nanofibrous membranes as bone scaffolds. Mater Sci Eng C Mater 69:1167–1174.  https://doi.org/10.1016/j.msec.2016.08.018 CrossRefGoogle Scholar
  5. 5.
    Islam A, Yasin T, Rehman I (2014) Synthesis of hybrid polymer networks of irradiated chitosan/poly(vinyl alcohol) for biomedical applications. Radiat Phys Chem 96:115–119.  https://doi.org/10.1016/j.radphyschem.2013.09.009 CrossRefGoogle Scholar
  6. 6.
    Sun X, Lu C, Liu Y, Zhang W, Zhang X (2014) Melt-processed poly(vinyl alcohol) composites filled with microcrystalline cellulose from waste cotton fabrics. Carbohydr Polym 101:642–649.  https://doi.org/10.1016/j.carbpol.2013.09.088 CrossRefGoogle Scholar
  7. 7.
    Hameed N, Glattauer V, Ramshaw JAM (2015) Evaluation of polyvinyl alcohol composite membranes containing collagen and bone particles. J Mech Behav Biomed 48:38–45.  https://doi.org/10.1016/j.jmbbm.2015.04.005 CrossRefGoogle Scholar
  8. 8.
    Ino JM, Sju E, Ollivier V, Yim EKF, Letourneur D, Le Visage C (2013) Evaluation of hemocompatibility and endothelialization of hybrid poly(vinyl alcohol) (PVA)/gelatin polymer films. J Biomed Mater Res-B 101(8):1549–1559.  https://doi.org/10.1002/jbm.b.32977 CrossRefGoogle Scholar
  9. 9.
    Yoon S-D, Park M-H, Byun H-S (2012) Mechanical and water barrier properties of starch/PVA composite films by adding nano-sized poly(methyl methacrylate-co-acrylamide) particles. Carbohydr Polym 87(1):676–686.  https://doi.org/10.1016/j.carbpol.2011.08.046 CrossRefGoogle Scholar
  10. 10.
    Luo X, Li J, Lin X (2012) Effect of gelatinization and additives on morphology and thermal behavior of corn starch/PVA blend films. Carbohydr Polym 90(4):1595–1600.  https://doi.org/10.1016/j.carbpol.2012.07.036 CrossRefGoogle Scholar
  11. 11.
    Grande R, Pessan LA, Carvalho AJF (2015) Ternary melt blends of poly(lactic acid)/poly(vinyl alcohol)-chitosan. Ind Crop Prod 72:159–165.  https://doi.org/10.1016/j.indcrop.2014.12.041 CrossRefGoogle Scholar
  12. 12.
    Wei Q, Zhang Y, Wang Y, Chai W, Yang M (2016) Measurement and modeling of the effect of composition ratios on the properties of poly(vinyl alcohol)/poly(vinyl pyrrolidone) membranes. Mater Des 103:249–258.  https://doi.org/10.1016/j.matdes.2016.04.087 CrossRefGoogle Scholar
  13. 13.
    Quero F, Coveney A, Lewandowska AE (2015) Stress transfer quantification in gelatin-matrix natural composites with tunable optical properties. Biomacromolecules 16(6):1784–1793.  https://doi.org/10.1021/acs.biomac.5b00345 CrossRefGoogle Scholar
  14. 14.
    Van Vlierberghe S, Dubruel P, Schacht E (2011) Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. Biomacromolecules 12(5):1387–1408.  https://doi.org/10.1021/bm200083n CrossRefGoogle Scholar
  15. 15.
    Elzoghby AO (2013) Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research. J Control Release 172(3):1075–1091.  https://doi.org/10.1016/j.jconrel.2013.09.019 CrossRefGoogle Scholar
  16. 16.
    Lim KS, Alves MH, Poole-Warren LA, Martens PJ (2013) Covalent incorporation of non-chemically modified gelatin into degradable PVA-tyramine hydrogels. Biomaterials 34(29):7097–7105.  https://doi.org/10.1016/j.biomaterials.2013.06.005 CrossRefGoogle Scholar
  17. 17.
    Mendieta-Taboada O, Sobral PJDA, Carvalho RA, Habitante AMBQ (2008) Thermomechanical properties of biodegradable films based on blends of gelatin and poly(vinyl alcohol). Food Hydrocoll 22(8):1485–1492.  https://doi.org/10.1016/j.foodhyd.2007.10.001 CrossRefGoogle Scholar
  18. 18.
    Pawde SM, Deshmukh K (2008) Characterization of polyvinyl alcohol/gelatin blend hydrogel films for biomedical applications. J Appl Polym Sci 109:3431–3437.  https://doi.org/10.1002/app.28454 CrossRefGoogle Scholar
  19. 19.
    Hago E, Li X (2013) Interpenetrating polymer network hydrogels based on gelatin and PVA by biocompatible approaches: synthesis and characterization. Adv Mater Sci Eng 2013:328763–328770.  https://doi.org/10.1155/2013/328763
  20. 20.
    Vasanthan KS, Subramaniam A, Krishnan UM, Sethuraman S (2015) Influence of 3D porous galactose containing PVA/gelatin hydrogel scaffolds on three-dimensional spheroidal morphology of hepatocytes. J Mater Sci Mater Med 26(1):1–20.  https://doi.org/10.1007/s10856-014-5345-7 CrossRefGoogle Scholar
  21. 21.
    Sarti B, Scandola M (1995) Viscoelastic and thermal properties of collagen/poly(vinyl alcohol) blends. Biomaterials 16(10):785–792.  https://doi.org/10.1016/0142-9612(95)99641-X CrossRefGoogle Scholar
  22. 22.
    Liu Y, Wang Q, Li L (2012) Biodegradable PVA/gelatin blends prepared by reactive extrusion. J Soc Leather Technol Chem 96:106–113Google Scholar
  23. 23.
    Wang N, Zhao L, Zhang C, Li L (2016) Water states and thermal processability of boric acid modified poly(vinyl alcohol). J Appl Polym Sci 133(13):43246–43252.  https://doi.org/10.1002/app.43246 Google Scholar
  24. 24.
    Wang B, Wang Q, Li L (2013) Morphology and properties of highly talc- and CaCO3-filled poly(vinyl alcohol) composites prepared by melt processing. J Appl Polym Sci 130(5):3050–3057.  https://doi.org/10.1002/app.39557 CrossRefGoogle Scholar
  25. 25.
    SHI X-PLAB (2005) Adsorption of fluoride on zirconium(IV)-impregnated collagen fiber. Environ Sci Technol 39:4628–4632CrossRefGoogle Scholar
  26. 26.
    Chen L, Ma L, Zhou M, Liu Y, Zhang Y (2014) Effects of pressure on gelatinization of collagen and properties of extracted gelatins. Food Hydrocoll 36:316–322.  https://doi.org/10.1016/j.foodhyd.2013.10.012 CrossRefGoogle Scholar
  27. 27.
    Ding J, Chen S, Wang X, Wang Y (2009) Synthesis and properties of thermoplastic poly(vinyl alcohol)-graft-lactic acid copolymers. Ind Eng Chem Res 48(2):788–793Google Scholar
  28. 28.
    Wang R, Wang Q, Li L (2003) Evaporation behaviour of water and its plasticizing effect in modified poly(vinyl alcohol) systems. Polym Int 52(12):1820–1826.  https://doi.org/10.1002/pi.1385 CrossRefGoogle Scholar
  29. 29.
    Li W, Xue F, Cheng R (2005) States of water in partially swollen poly(vinyl alcohol) hydrogels. Polymer 46(25):12026–12031.  https://doi.org/10.1016/j.polymer.2005.09.016 CrossRefGoogle Scholar
  30. 30.
    Hodge RM, Bastow TJ, Edward GH, Simon GP, Hill AJ (1996) Free volume and the mechanism of plasticization in water-swollen poly(vinyl alcohol). Macromolecules 29(25):8137–8143CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  1. 1.State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan UniversityChengduChina

Personalised recommendations