Journal of Polymer Research

, 24:167 | Cite as

Synthesis of lactate (LA)-based poly(ester-urethane) using hydroxyl-terminated LA-based oligomers from a microbial secretion system

  • Camila Utsunomia
  • Tatsuya Saito
  • Ken’ichiro Matsumoto
  • Chiaki Hori
  • Takuya Isono
  • Toshifumi Satoh
  • Seiichi TaguchiEmail author
Part of the following topical collections:
  1. Topical Collection on Bio-Based Polymers


D-Lactate (LA)-based oligomers (D-LAOs), consisting of D-LA and D-3-hydroxybutyrate (D-3HB), are biobased compounds which are produced and spontaneously secreted by recombinant Escherichia coli. By supplementing the bacterial cultivation with diethylene glycol (DEG), the oligomers featuring hydroxyl groups at both ends of their structures, the D-LAOs-DEG, can be efficiently biosynthesized. In the present work, we attempted to verify the feasibility of D-LAOs-DEG as building blocks to be assembled into LA-based poly(ester-urethane) via polyaddition reaction with diisocyanate. The polymeric products were demonstrated by SEC and the urethane bound formation in the polymer was determined by FT-IR analysis, indicating that the polymerization was successfully performed. These results suggested that the one-step biosynthesized D-LAOs-DEG are potential substrates for the synthesis of LA-based poly(ester-urethane) and can be further applied to the synthesis of other LA copolymers.


Polyhydroxyalkanoate Polylactic acid Oligoester Biobased plastic Polyurethane Microbial factory 



ESI-TOF-MS was measured using the Open Facility of the Center for Advanced Research of Energy Conversion Material, Hokkaido University. This study was partially supported by CREST, JST (JPMJCR12B4 to S.T. and K.M.).


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Camila Utsunomia
    • 1
  • Tatsuya Saito
    • 1
  • Ken’ichiro Matsumoto
    • 2
    • 3
  • Chiaki Hori
    • 2
    • 3
  • Takuya Isono
    • 2
  • Toshifumi Satoh
    • 2
  • Seiichi Taguchi
    • 2
    • 3
    • 4
    Email author
  1. 1.Graduate School of Chemical Sciences and EngineeringHokkaido UniversitySapporoJapan
  2. 2.Division of Applied Chemistry, Faculty of EngineeringHokkaido UniversitySapporoJapan
  3. 3.CREST, JSTSaitamaJapan
  4. 4.Department of Chemistry for Life Sciences and Agriculture, Faculty of Life SciencesTokyo University of AgricultureTokyoJapan

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