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A novel biocompatible magnetic iron oxide nanoparticles/hydrogel based on poly (acrylic acid) grafted onto starch for controlled drug release

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Abstract

In this paper, a novel biocompatible magnetic iron oxide nanoparticles/hydrogel was synthesized based on the simultaneous formation of magnetic iron oxide nanoparticles (MION) and hydrogel based on poly (acrylic acid) grafted onto starch (PAA-g-starch). The structural, morphological and magnetic properties of the optimized sample were characterized by scanning electron microscopy with energy dispersive X-ray analysis (SEM–EDAX), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). In addition, the effect of external magnetic field (EMF), pH, and temperature on the swelling of the MION-PAA-g-starch hydrogel was studied. The results showed that the EMF reduced the swelling capacity of MION-PAA-g-starch hydrogel. Moreover, the in vitro release of deferasirox was studied in pH = 2 and 7 under EMF. The release curves were nicely fitted by the Korsemeyer–Peppas equation and the release followed by non-Fickian diffusion.

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Acknowledgments

We are grateful to the PNU and INSF for funding this work.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran

    Ghasem Rezanejade Bardajee & Zari Hooshyar

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  1. Ghasem Rezanejade Bardajee
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  2. Zari Hooshyar
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Correspondence to Ghasem Rezanejade Bardajee.

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Bardajee, G.R., Hooshyar, Z. A novel biocompatible magnetic iron oxide nanoparticles/hydrogel based on poly (acrylic acid) grafted onto starch for controlled drug release. J Polym Res 20, 298 (2013). https://doi.org/10.1007/s10965-013-0298-y

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  • DOI: https://doi.org/10.1007/s10965-013-0298-y

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