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Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes

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Abstract

In this study, we prepared electrospun polycaprolactone/polyethylene oxide (PCL/PEO) membranes fabricated by electrospinning. We designed the membranes for the application of medical patch. In order to understand the drug-released behavior when the membranes were used in medical patch, ketoprofen was used as a model drug. The results show that ketoprofen-loaded electrospun membranes that comprised PCL/PEO released all ketoprofen in 30 min. The mebranes had potential application in medical patch. In additions, the viscosity of the PCL/PEO solution increased with the proportion of PEO. The low conductivities of the all PCL/PEO solutions were caused by the lack of electric charge on both PCL and PEO molecules. A higher PEO percentage was associated with high enthalpy of fusion of the electrospun PCL/PEO membrane. The crystallinity of PEO in the PCL/PEO composite decreased as the PEO content declined.

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Acknowledgment

The authors would like to thank the National Science Council, Taiwan for financial support (97-2622-E-224-017-CC3).

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Authors and Affiliations

  1. Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Douliou, Taiwan

    Yu-Hsun Nien, Chien-Ju Lu & Quan-Xun Ye

  2. Department of Polymer Materials, Kun Shan University, Yung Kang city, Taiwan

    Chung-Yang Shih & Chih-Yuan Yang

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  1. Yu-Hsun Nien
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  2. Chung-Yang Shih
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  3. Chih-Yuan Yang
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  4. Chien-Ju Lu
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Correspondence to Yu-Hsun Nien.

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Nien, YH., Shih, CY., Yang, CY. et al. Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes. J Polym Res 20, 166 (2013). https://doi.org/10.1007/s10965-013-0166-9

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  • DOI: https://doi.org/10.1007/s10965-013-0166-9

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