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Preparation and characterization of phosphorylcholine glyceraldehyde grafted polycarbonateurethane films

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Abstract

Phosphorylcholine glyceraldehyde (PCGA), the aldehyde derivative of L-α-glycerylphosphorylcholine (GPC), was covalently linked onto polycarbonateurethane (PCU) surface in order to introduce biomimetic structure on its surface. PCGA was grafted onto PCU surface via three coupling reactions on PCU surface using hexamethylene diisocyanate (HDI) and tris(2-aminoethyl)amine (TAEA) as spacers. X-ray photoelectron spectroscopy (XPS), fourier transform infrared (FTIR) spectroscopy and water contact angle measurements verified that PCGA had already been grafted onto PCU surfaces. In addition, surface morphology of PCGA grafted PCU film was observed using atomic force microscope (AFM), which showed that the grafted film has a pin-hole free surface which is rougher than the surface of blank PCU film. Scanning electron microscope (SEM) observation of the modified PCU films after treated with platelet-rich plasma demonstrated that much fewer platelets adhered to the surfaces of the grafted PCU films than to the surface of blank PCU film. The result suggested that these PCGA grafted polymers may have potential application as biomaterials for vascular grafts and some subcutaneously implanted devices.

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Acknowledgements

This work has been supported by the Program for New Century Excellent Talents in University NCET-07-0596, Ministry of Education of P. R. China, the International Cooperation from Ministry of Science and Technology of China (Grant No. 2008DFA51170) as well as by the Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine.

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, 300072, China

    Jian Lu, Yakai Feng, Bin Gao & Jintang Guo

  2. Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin, 300072, China

    Yakai Feng & Jintang Guo

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  1. Jian Lu
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  2. Yakai Feng
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  3. Bin Gao
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  4. Jintang Guo
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Correspondence to Yakai Feng or Jintang Guo.

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Lu, J., Feng, Y., Gao, B. et al. Preparation and characterization of phosphorylcholine glyceraldehyde grafted polycarbonateurethane films. J Polym Res 19, 9959 (2012). https://doi.org/10.1007/s10965-012-9959-5

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  • DOI: https://doi.org/10.1007/s10965-012-9959-5

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