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Rapid preparation of monodisperse biodegradable polymer nanospheres using a membrane emulsification technique under low gas pressure

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Abstract

Nanospheres of poly(lactide-co-glycolide) (PLGA), a biodegradable polymer, have been prepared using the conventional solvent diffusion method. In this study, a method combining the solvent diffusion method and a two-step (premix) membrane emulsification technique is proposed for the preparation of monodisperse PLGA nanospheres with a diameter of 200 nm. The monodispersity of the PLGA nanospheres was higher than that of nanospheres obtained by the conventional solvent diffusion method. Generally, preparation of small particles or droplets by the membrane emulsification technique requires a supply of high-pressure nitrogen gas to force the emulsion or dispersion solution through the small pores of the membrane. However, in the technique proposed here, low-pressure nitrogen gas (0.02–0.11 kgf/cm2) is sufficient. Thus, using this technique, one can obtain monodisperse PLGA nanospheres with a diameter of 200 nm in a relatively short period of time under low-pressure nitrogen gas.

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Authors and Affiliations

  1. Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, Tokyo, 192-0397, Japan

    Fuminori Ito

  2. Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan

    Yurie Kanakubo & Yoshihiko Murakami

  3. Kogasaka 495-13, Machida-shi, Tokyo, 194-0014, Japan

    Fuminori Ito

Authors
  1. Fuminori Ito
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  2. Yurie Kanakubo
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  3. Yoshihiko Murakami
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Correspondence to Fuminori Ito.

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Ito, F., Kanakubo, Y. & Murakami, Y. Rapid preparation of monodisperse biodegradable polymer nanospheres using a membrane emulsification technique under low gas pressure. J Polym Res 18, 2077–2085 (2011). https://doi.org/10.1007/s10965-011-9617-3

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  • DOI: https://doi.org/10.1007/s10965-011-9617-3

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