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Synthesis and characterization of pH- and thermoresponsive Poly(N-isopropylacrylamide-co-itaconic acid) hydrogels crosslinked with N-maleyl chitosan

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Abstract

Biodegradable cross-linker N-maleyl chitosan (N-MACH) was synthesized with chitosan (CS) and maleic anhydride (MA) by acylation. With N-MACH cross-linker, a series of cross-linked poly(N-isopropylacrylamide-co-itaconic acid) [P(NIPAAm-co-IA)] hydrogels were prepared, and their pH-and temperature-responsive behaviors, water contents, swelling/deswelling kinetics were investigated. By alternating the NIPAAm/IA weight ratios, hydrogels had the volume phase transition temperature (VPTT) changed from 33 to 38 °C, whereas cross-linking density did not affect the VPTT apparently. The water content of hydrogels was controlled by the monomer weight ratios of NIPAAm/IA, swelling media, and the cross-linking density. The results of the influence of pH value on the swelling behaviors showed that the minimum swelling ratios of the hydrogels appeared in neutral buffer solution, which was attributed to chemical composition of the hydrogels and the swelling media. In the swelling/deswelling kinetics, all the dried hydrogels exhibited fast swelling within 480 min and fast deswelling within 20 min, which was independent of the content of IA and cross-linker.

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Acknowledgment

This study was supported by the National Natural Science Foundation of China (No. 20876081), and the Science Foundation of Shandong Province (No.Y2006B10), Qingdao Science and Technology Program for basic research projects (09-1-3-33-JCH).

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Authors and Affiliations

  1. Key Laboratory of Eco-chemical Engineering, Ministry of Education; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People’s Republic of China

    Yueqin Yu, Yanshun Li, Lingxiu Liu, Chunjing Zhu & Yang Xu

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  1. Yueqin Yu
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  2. Yanshun Li
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  3. Lingxiu Liu
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  4. Chunjing Zhu
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Correspondence to Yueqin Yu.

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Yu, Y., Li, Y., Liu, L. et al. Synthesis and characterization of pH- and thermoresponsive Poly(N-isopropylacrylamide-co-itaconic acid) hydrogels crosslinked with N-maleyl chitosan. J Polym Res 18, 283–291 (2011). https://doi.org/10.1007/s10965-010-9417-1

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