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Influence of experimental parameters and the copolymer structure on the size control of nanospheres in double emulsion method

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Abstract

Poly(lactide-ethylene glycol) (PLEG) and poly(lactide-methoxy poly(ethylene glycol)) (MePLEG) nanospheres used as drug carrier were prepared by a double emulsion method. The influences of several parameters, such as copolymer structure, phase volume ratios, emulsifer concentration and sonication parameters, on the preparation of these two copolymer nanospheres were investigated for the nanospheres control. Critical values of the emulsifer concentration and the sonication intensity exist, allowing optimization of the nanospheres of controlled size with a narrow distribution. Under the same condition, MePLEG nanospheres had a smaller size than PLEG nanospheres because of their different length of hydrophilic blocks and steric hindrance. In addition, vascular endothelial cell growth factor and cisplatin, as two water-soluble model drugs, were encapsulated in the MePLEG and PLEG nanospheres. A higher encapsulation efficiency, above 90%, of the PLEG nanospheres could be obtained than that of the MePLEG nanospheres because of their different hydrophilic blocks structure.

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Acknowledgements

This work was financially supported by National Natural Science Foundation of China (Project No. 30600751 and 30772349), Science and Technology Committee of Shanghai (Project No. 05XD14015) and Shanghai Education Committee (Project No. 09YZ103). We thank Instrumental Analysis Center of Shanghai Jiao Tong University for the help in characterization.

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Authors and Affiliations

  1. The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, People’s Republic of China

    Bin Xu, Hongjing Dou, Ke Tao, Kang Sun & Rong Lu

  2. Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, People’s Republic of China

    Weibin Shi

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  1. Bin Xu
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  2. Hongjing Dou
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  3. Ke Tao
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  4. Kang Sun
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Correspondence to Weibin Shi.

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Xu, B., Dou, H., Tao, K. et al. Influence of experimental parameters and the copolymer structure on the size control of nanospheres in double emulsion method. J Polym Res 18, 131–137 (2011). https://doi.org/10.1007/s10965-010-9399-z

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  • DOI: https://doi.org/10.1007/s10965-010-9399-z

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