Abstract
A new glycoconjugate polyacrylamide with water-solubility and additional activated groups was prepared by attaching glucosamine to the preactivated polymer, Poly(N-acryloylmorpholine-co-N-acryloxysuccinimide) [poly(NAM-co-NAS)]. The structures of glycoconjugate polyacrylamide were characterized by 1H-NMR, FTIR and GPC. The glucosamine conjugates degrees were determined by the modified Schales’ method and the contents of activated groups were measured by the isopropylamine method. The results showed that this new glycopolymer is water-soluble and has additional activated groups. And high molecular weight confirmed the high number of activated groups per polymer chain, though the N-oxysuccinimide groups were partly shielded by the N-morpholine groups.
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Teng, D., Yin, W., Zhang, X. et al. New glycoconjugate polyacrylamide with water-solubility and additional activated groups: synthesis and characterization. J Polym Res 16, 311–316 (2009). https://doi.org/10.1007/s10965-008-9231-1
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DOI: https://doi.org/10.1007/s10965-008-9231-1